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Crosslinking, Labeling and Protein Modification

A variety of reagents used to modify proteins for identification, analysis, research, and other applications.
Protein Labeling Reagents (38)
Crosslinking Reagents (22)
Protein Modification Reagents (7)

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1 – 15 of 54 results
1

Thermo Scientific™ CT(PEG)12 Carboxy-PEG-Thiol Compound

CT(PEG)n: carboxylic acid and sulfhydryl compound with a 12-unit polyethylene glycol (PEG) spacer; carboxylate and pegylate quantum dots, gold surfaces, silver.

2

Thermo Scientific™ MT(PEG)4 Methyl-PEG-Thiol Compound

MT(PEG)n: methyl and sulfhydryl compound with a 4-unit polyethylene glycol (PEG) spacer; methylate and pegylate quantum dots, gold surfaces, silver.

3

Thermo Scientific™ Pierce™ Iodoacetic Acid

Get rapid carboxymethylation of reduced cysteine residues with Thermo Scientific™ Pierce™ Iodoacetic Acid and Iodoacetamide.

EDGE
4

Thermo Scientific™ Pierce™ Sulfo-SANPAH, No-Weigh™ Format

EDGE
Shipping Condition Ambient
Content And Storage Upon receipt store at -20°C protected from light and moisture.
Cleavable By Thiols
Water Soluble Yes
Form Powder
Molecular Weight (g/mol) 492.4
Solubility Water
Labeling Method Chemical Labeling
Crosslinker Type Heterobifunctional
Chemical Reactivity Amine-Nonselective
Cell Permeability No
Format Standard, Single-use
Product Type Crosslinker
Spacer Medium (10 to 30 Å)
Spacer Arm Length 18.2 Å
PEGylated No
5

Thermo Scientific™ EZ-Link™ Maleimide-PEG2-Biotin, No-Weigh™ Format

Biotinylate reduced cysteines with this short, maleimide-activated, sulfhydryl-reactive biotinylation reagent containing a 2-unit PEG spacer arm to enhance water solubility.

EDGE
Cell Permeability Cell-Impermeant
Product Type Maleimide-PEG2-Biotin
Label or Dye Biotin
Solubility DMF (Dimethylformamide),DMSO (Dimethylsulfoxide),Water
Reactive Moiety Maleimide
Chemical Reactivity Thiol
Product Line EZ-Link™
6

Thermo Scientific™ EZ-Link™ Maleimide-PEG11-Biotin

Biotinylate reduced cysteines with this long, maleimide-activated, sulfhydryl-reactive biotinylation reagent with an 11-unit PEG spacer arm to enhance solubility and reach.

EDGE
7

Thermo Scientific™ Pierce™ DSP, No-Weigh™ Format

Crosslink amines to amines with dithiobis succinimidyl propionate, composed of NHS-ester groups and disulfide-containing, 12.0A spacer arm and cleavable with reducing agents.

EDGE
Content And Storage Upon receipt store desiccated at 4°C.
Description DSP
Cleavable By Thiols
Water Soluble No
Form Powder
Molecular Weight (g/mol) 404.42
Solubility DMF, DMSO
Labeling Method Chemical Labeling
Crosslinker Type Homobifunctional
Chemical Reactivity Amine-Amine
Cell Permeability Yes
Format Standard, Single-use, Premium-grade
Product Type Crosslinker
Spacer Medium (10 to 30 Å)
Reactive Moiety NHS Ester
Spacer Arm Length 12.0 Å
PEGylated No
8

Thermo Scientific™ Pierce™ Premium Grade DSP (dithiobis(succinimidyl propionate))

Optimize applications where product integrity and risk minimization are paramount with our highest quality formulation of this popular amine-reactive, cleavable crosslinker.

EDGE
Shipping Condition Ambient
Content And Storage Upon receipt store desiccated at 4°C.
Cleavable By Thiols
Water Soluble No
Form Powder
Molecular Weight (g/mol) 404.42
Solubility DMF, DMSO
Labeling Method Chemical Labeling
Crosslinker Type Homobifunctional
Chemical Reactivity Amine-Amine
Cell Permeability Yes
Format Standard, Single-use, Premium-grade
Product Type Crosslinker
Spacer Medium (10 to 30 Å)
Formulation Dithiobis(succinimidylpropionate); powder solid
Reactive Moiety NHS Ester
Spacer Arm Length 12.0 Å
Product Line Pierce™
PEGylated No
9

Thermo Scientific™ Pierce™ MMTS (methyl methanethiosulfonate)

Methyl methanethiosulfonate (CAS 2949-92-0); reversibly blocks cysteines (sulfhydryl groups) to facilitate study of enzyme activation and protein functions.

10

Thermo Scientific™ Pierce™ NEM (N-ethylmaleimide)

Small, sulfhydryl-reactive (maleimide) compound to permanently block reduced cysteines of proteins or peptides to prevent disulfide bond formation.

11

Thermo Scientific™ EZ-Link™ Iodoacetyl-PEG2-Biotin

Biotinylate reduced cysteines (-SH groups) at high pH with this haloacetyl-activated, sulfhydryl-reactive biotinylation reagent containing polyethylene glycol for solubility.

12

Thermo Scientific™ EZ-Link™ HPDP-Biotin, No-Weigh™ Format

Solubility DMF (Dimethylformamide),DMSO (Dimethylsulfoxide)
Label Type Biotin & Analogs
13

Thermo Scientific™ MM(PEG)24 Methyl-PEG-Maleimide Reagent

Pegylate sulfhydryls (-SH groups) on proteins (cysteine residues) or assay surfaces using MS(PEG); sulfhydryl-reactive (maleimide), PEG compounds (12 and 24 EG units).

14

Thermo Scientific™ MM(PEG)12 Methyl-PEG-Maleimide Reagent

Pegylate sulfhydryls (-SH groups) on proteins (cysteine residues) or assay surfaces using MS(PEG); sulfhydryl-reactive (maleimide), PEG compounds (12 and 24 EG units).

15

Thermo Scientific™ SPDP (succinimidyl 3-(2-pyridyldithio)propionate)

Crosslink amines to sulfhydryls with this crosslinker composed of NHS-ester and pyridyldithiol groups on 3-atom spacer arm; forms cleavable disulfide bonds with cysteines.