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ACROBiosystems Rat CTLA-4 / CD152 Protein, Fc Tag
326.60€ - 2325.44€
Specifications
| Molecular Weight (g/mol) | 40.2 kDa |
|---|---|
| Source | Rat CTLA-4, Fc Tag (CT4-R5259) is expressed from human 293 cells (HEK293). It contains AA Ile 38 - Asp 161 (Accession # Q62859). |
| Immunogen | Ile 38 - Asp 161 |
| Storage Requirements | -20°C |
| Gene Alias | CTLA4,CD152 |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
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15836537
|
ACROBiosystems
CT4-R5259-1MG |
1 mg |
2325.44€
1mg |
Estimated Shipment: 26-04-2024
Log in to see stock. |
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|
15826537
|
ACROBiosystems
CT4-R5259-100UG |
100 μg |
326.60€
100µg |
Estimated Shipment: 26-04-2024
Log in to see stock. |
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Description
CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis.
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 40.2 kDa. The protein migrates as 50-55 kDa under reducing (R) condition (SDS-PAGE).Specifications
| 40.2 kDa | |
| Ile 38 - Asp 161 | |
| CTLA4,CD152 | |
| Unconjugated | |
| Fc Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >95% as determined by SDS-PAGE |
| Rat CTLA-4, Fc Tag (CT4-R5259) is expressed from human 293 cells (HEK293). It contains AA Ile 38 - Asp 161 (Accession # Q62859). | |
| -20°C | |
| CTLA-4 | |
| Rat | |
| Tris with Glycine, Arginine and NaCl, pH7.5 | |
| HEK293 | |
| Immune Checkpoint Proteins |