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Rapamycin, 98+%, Thermo Scientific Chemicals
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Quantity:
100 mg
Description
Blocks cytokine-mediated signal transduction pathwaysRapamycin is used to inhibit tumor growth by halting tumor cell proliferation and suppressing tumor angiogenesis. It forms a complex with FKBP12 that binds and inhibits the molecular target of rapamycin (mTOR) as well as suppresses the immune system, preventing transplant rejection.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
- Rapamycin is a natural macrolide compound showing antiproliferative activities in mammalian cells
- Rapamycin is a specific inhibitor of rapamycin kinase. It forms a complex with FKBP12 that consequently binds and inhibits rapamycin’s molecular target (rapamycin kinase)
Application
- Rapamycin inhibits tumor growth by preventing tumor cell proliferation and suppressing tumor angiogenesis
- This compound also blocks cytokine-mediated signal transduction pathways
- Rapamycin also promotes the suppression of the immune system
- It was initially defined as an antifungal metabolite produced by Streptomyces hygroscopicus
- In vitro studies demonstrated that this compound is an important mediator of PI3 kinase signaling
Specifications
| Type | Rapamycin |
| Physical Form | Powder |
| Merck Index | 14,8114 |
| Solubility Information | Soluble in DMSO at 50mg/ml or methanol at 25mg/mlSoluble in alcohol,dimethyl sulfoxide and dimethyl formamide; Insoluble in water. |
| Formula Weight | 914.17 |
| Percent Purity | ≥99% |
| Color | White |
| Quantity | 100 mg |
| Chemical Name or Material | Rapamycin |
Safety and Handling
Signal Word
- Danger
- Carcinogenicity Category 2
- Reproductive toxicity Category 2
- Specific target organ toxicity Category 1
- H351-Suspected of causing cancer.
- H361-Suspected of damaging fertility or the unborn child.
- H372-Causes damage to organs.
- P201-Obtain special instructions before use.
- P280-Wear protective gloves/protective clothing/eye protection/face protection.
- P308+P313-IF exposed or concerned: Get medical advice/attention.
RUO – Research Use Only
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