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ACROBiosystems Rabbit CTLA-4 / CD152 Protein, Fc Tag

Brand:  ACROBiosystems CT4-R5250-1MG

Additional Details : Weight : 0.00001kg

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Product Code. 15816537

  • 2219.34€ / 1mg


Estimated Shipment: 28-10-2021
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Description

Description

CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis.

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 40.3 kDa. The protein migrates as 50-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Specifications

Specifications

Less than 1.0 EU / µg by the LAL method.
Immune Checkpoint Proteins
Powder
>95% as determined by SDS-PAGE
Rabbit CTLA-4, Fc Tag (CT4-R5250) is expressed from human 293 cells (HEK293). It contains AA Lys 36 - Asp 161 (Accession # P42072).
-20°C
CTLA-4
Fc Tag
HEK293
Rabbit
40.3 kDa
1 mg
Lys 36 - Asp 161
CTLA4,CD152
Unconjugated
Tris with Glycine, Arginine and NaCl, pH7.5
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