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ACROBiosystems Mouse FOLR1 Protein, His Tag

414.60€ - 3018.82€

Specifications

Accession Number NP_032060.2
Molecular Weight (g/mol) 26.2 kDa
Source Mouse FOLR1, His Tag (FO1-M5225) is expressed from human 293 cells (HEK293). It contains AA Thr 25 - Ser 232 (Accession # P35846-1).
Immunogen Thr 25 - Ser 232
Storage Requirements -20°C
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Product Code Brand Quantity Price Quantity & Availability  
15826787
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ACROBiosystems
FO1-M5225-1MG
1 mg
3018.82€
1mg
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15816787
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ACROBiosystems
FO1-M5225-100UG
100 μg
414.60€
100µg
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Description

Description

Folate Receptor 1 (FOLR1) is also known as Folate receptor alpha, Folate Binding Protein (FBP), FOLR, and is a member of the folate receptor (FOLR) family. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. Mature FOLR1 is an N-glycosylated protein that is anchored to the cell surface by a GPI linkage. FOLR1 is predominantly expressed on epithelial cells and is dramatically upregulated on many carcinomas. FOLR1 is internalized to the endosomal system where it dissociates from its ligand before recycling to the cell surface. A soluble form of FOLR1 can be proteolytically shed from the cell surface into the serum and breast milk. Defects in FOLR1 are the cause of neurodegeneration due to cerebral folate transport deficiency (NCFTD). NCFTD is an autosomal recessive disorder resulting from brain-specific folate deficiency early in life.

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 26.2 kDa. The protein migrates as 32-34 kDa and 35-40 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Specifications

Specifications

NP_032060.2
Mouse FOLR1, His Tag (FO1-M5225) is expressed from human 293 cells (HEK293). It contains AA Thr 25 - Ser 232 (Accession # P35846-1).
-20°C
FOLR1
Mouse
Tris and Glycine, pH7.5
HEK293
Bio-Markers and CD Antigens
26.2 kDa
Thr 25 - Ser 232
FOLR-1,FBP,FOLR
Unconjugated
His Tag
Less than 1.0 EU / μg by the LAL method.
Powder
>95% as determined by SDS-PAGE
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