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ACROBiosystems Mouse B7-2 / CD86 Protein, Fc Tag
235.15€ - 1424.00€
Specifications
Accession Number | NP_062261.3 |
---|---|
Molecular Weight (g/mol) | 51.9 kDa |
Source | Mouse B7-2, Fc Tag (CD6-M5251) is expressed from human 293 cells (HEK293). It contains AA Val 24 - Glu 245 (Accession # NP_062261.3). |
Immunogen | Val 24 - Glu 245 |
Storage Requirements | -20°C |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
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Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
15826247
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ACROBiosystems
CD6-M5251-1MG |
1 mg |
1424.00€
1mg |
Estimated Shipment: 30-04-2024
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15816247
|
ACROBiosystems
CD6-M5251-100UG |
100 μg |
235.15€
100µg |
Estimated Shipment: 30-04-2024
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Description
Cluster of Differentiation 86 (CD86) is also known as B-lymphocyte activation antigen B7-2, is a type I membrane protein that is a member of the immunoglobulin superfamily, and is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells. Additionally, B72 is expressed at low levels on monocytes and can be upregulated through interferon γ. CD86 is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD86 works in tandem with CD80 to prime T cells. Recent study has revealed that B7-2 promotes the generation of a mature APC repertoire and promotes APC function and survival. Furthermore, the B7 proteins are also involved in innate immune responses by activating NF-κB-signaling pathway in macrophages. CD86 thus is regarded as a promising candidate for immune therapy. CD86+ macrophages in Hodgkin lymphoma patients are an independent marker for potential nonresponse to firstline-therapy.
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 51.9 kDa. The protein migrates as 66-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Specifications
NP_062261.3 | |
Mouse B7-2, Fc Tag (CD6-M5251) is expressed from human 293 cells (HEK293). It contains AA Val 24 - Glu 245 (Accession # NP_062261.3). | |
-20°C | |
B7-2 | |
Mouse | |
Tris with Glycine, Arginine and NaCl, pH7.5 | |
HEK293 | |
Immune Checkpoint Proteins |
51.9 kDa | |
Val 24 - Glu 245 | |
CD86,B7-2,B70,CD28LG2,LAB72,MGC34413 | |
Unconjugated | |
Fc Tag | |
Less than 1.0 EU / μg by the LAL method. | |
Powder | |
>95% as determined by SDS-PAGE |