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  5. Tocris Bioscience™ Masitinib

Tocris Bioscience™ Masitinib
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Product Code. 18778176
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Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
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Product Code. 18778176

Brand: Tocris Bioscience™ 7705/10

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Description

Potent colony-stimulating factor 1 receptor (CSF-1R) tyroine kinase inhibitor

Masitinib is a potent inhibitor of the tyrosine kinase receptor colony-stimulating factor 1R (CSF-1R) (IC50 = 90 nM). It is also an NLRP3 inflammasome activator. Masitinib additionally inhibits the proteolytic activity of SARS-CoV-2 main protease (Mpro) and blocks viral replication, as well as acting as a PDGFRα/β inhibitor. In vivo, Masitinib ameliorates cognitive impairment in transgenic mice model of Alzheimer's disease, and slows disease progression in a rat model of amyotrophic lateral sclerosis (ALS). Orally bioavailable.
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Specifications

Chemical Name or Material 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-thiazolyl]amino]phenyl]benzamide
CAS 790299-79-5
Quantity 10 mg
Target CD117/c-kit
Molecular Formula C28H30N6OS
Purity 0.98
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