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ACROBiosystems Human Sonic Hedgehog / Shh Protein, His Tag

259.13€ - 2383.96€

Specifications

Accession Number NP_000184
Molecular Weight (g/mol) 20.4 kDa
Source Human Sonic Hedgehog, His Tag (SH7-H5229) is expressed from human 293 cells (HEK293). It contains AA Cys 24 - Gly 197 (Accession # NP_000184).
Immunogen Cys 24 - Gly 197
Storage Requirements -20°C
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Product Code Brand Quantity Price Quantity & Availability  
15807687
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ACROBiosystems
SH7-H5229-1MG
1 mg
2383.96€
1mg
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15817687
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ACROBiosystems
SH7-H5229-50UG
50 μg
259.13€
50µg
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Description

Description

Sonic hedgehog protein (SHH) is also known as HHG-1, which belongs to the hedgehog family. SHH is expressed in fetal intestine, liver, lung, and kidney and not expressed in adult tissues. Sonic hedgehog protein can be cleavage into sonic hedgehog protein N-product and sonic hedgehog protein C-product by autolysis. SHH binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development. The C-terminal domain displays an autoproteolysis activity and a cholesterol transferase activity. The N-product is the active species in both local and long-range signaling, whereas the C-product has no signaling activity.

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 20.4 kDa. The protein migrates as 23-25 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Specifications

Specifications

NP_000184
Human Sonic Hedgehog, His Tag (SH7-H5229) is expressed from human 293 cells (HEK293). It contains AA Cys 24 - Gly 197 (Accession # NP_000184).
-20°C
Sonic Hedgehog
Human
PBS, pH7.4
HEK293
Cytokines and Growth Factors
20.4 kDa
Cys 24 - Gly 197
SHH,HHG-1,Sonic hedgehog,HLP3,HPE3,SMMCI,TPT,TPTPS
Unconjugated
His Tag
Less than 1.0 EU / μg by the LAL method.
Powder
>95% as determined by SDS-PAGE
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