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ACROBiosystems Human PD-L1 / B7-H1 Protein, Fc Tag
MALS verified
418.06€ - 3357.52€
Specifications
| Accession Number | NP_054862.1 |
|---|---|
| Molecular Weight (g/mol) | 51.3 kDa |
| Source | Human PD-L1, Fc Tag (PD1-H5258) is expressed from human 293 cells (HEK293). It contains AA Phe 19 - Arg 238 (Accession # NP_054862.1). |
| Immunogen | Phe 19 - Arg 238 |
| Storage Requirements | -20°C |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
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15807467
|
ACROBiosystems
PD1-H5258-1MG |
1 mg |
3357.52€
1mg |
Estimated Shipment: 08-05-2024
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|
15897457
|
ACROBiosystems
PD1-H5258-100UG |
100 μg |
418.06€
100µg |
Estimated Shipment: 08-05-2024
Log in to see stock. |
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Description
Programmed cell death 1 ligand 1 (PD-L1) is also known as cluster of differentiation (CD274) or B7 homolog 1 (B7-H1), is a member of the growing B7 family of immune molecules and is involved in the regulation of cellular and humoral immune responses. B7-H1 is a cell surface immunoglobulin superfamily with two Ig-like domains within the extracellular region and a short cytoplasmic domain. PD-L1 is highly expressed in the heart, skeletal muscle, placenta and lung and weakly expressed in the thymus, spleen, kidney and liver. PD-L1 is expressed on activated T-cells, B-cells, dendritic cells, keratinocytes and monocytes. PD-L1 is up-regulated on T- and B-cells, dendritic cells, keratinocytes and monocytes after LPS and IFNG activation and up-regulated in B-cells activated by surface Ig cross-linking. PD-L1 involve in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner.
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 51.3 kDa. The protein migrates as 60-75 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Specifications
| NP_054862.1 | |
| Human PD-L1, Fc Tag (PD1-H5258) is expressed from human 293 cells (HEK293). It contains AA Phe 19 - Arg 238 (Accession # NP_054862.1). | |
| -20°C | |
| PD-L1 | |
| Human | |
| PBS, pH7.4 | |
| HEK293 | |
| Immune Checkpoint Proteins |
| 51.3 kDa | |
| Phe 19 - Arg 238 | |
| PD-L1,CD274,B7-H1,PDCD1L1,PDCD1LG1 | |
| Unconjugated | |
| Fc Tag | |
| Less than 0.1 EU / μg by the LAL method. | |
| Powder | |
| >95% as determined by SDS-PAGE |