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ACROBiosystems Human Osteoactivin / GPNMB Protein, His Tag
Brand: ACROBiosystems GPB-H5229-100UG
Additional Details : Weight : 0.00001kg
Description
Transmembrane glycoprotein NMB (GPNMB) is also known as Transmembrane glycoprotein HGFIN, DC-HIL and Osteoactivin (OA), which belongs to the PMEL/NMB family. GPNMB contains one PKD domain. GPNMB is a transmembrane glycoprotein that is up-regulated in various cancer cells, including in glioblastoma multiforme and is expressed in many melanoma cells, as well as in tissue macrophages. GPNMB protein acts as a downstream mediator of BMP-2 effects on osteoblast differentiation and function. GPNMB participates in bone mineralization, and functions as a negative regulator of inflammation in macrophages.
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 53.4 kDa. The protein migrates as 85-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Specifications
| AAH32783 | |
| 100 μg | |
| Ala 22 - Pro 486 | |
| GPNMB,HGFIN,NMB,Osteoactivin | |
| Unconjugated | |
| His Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >95% as determined by SDS-PAGE |
| 53.4 kDa | |
| Human Osteoactivin, His Tag (GPB-H5229) is expressed from human 293 cells (HEK293). It contains AA Ala 22 - Pro 486 (Accession # AAH32783). | |
| -20°C | |
| Osteoactivin | |
| Human | |
| PBS, pH7.4 | |
| HEK293 | |
| Bio-Markers and CD Antigens |