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ACROBiosystems Human Nectin-3 / CD113 Protein, His Tag
391.93€ - 2612.85€
Specifications
| Accession Number | Q9NQS3 |
|---|---|
| Molecular Weight (g/mol) | 39.6 kDa |
| Source | Human Nectin-3, His Tag (PV3-H52E4) is expressed from human 293 cells (HEK293). It contains AA Gly 58 - Asp 400 (Accession # Q9NQS3). |
| Immunogen | Gly 58 - Asp 400 |
| Storage Requirements | -20°C |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
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15817577
|
ACROBiosystems
PV3-H52E4-100UG |
100 μg |
391.93€
100µg |
Estimated Shipment: 08-05-2024
Log in to see stock. |
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|
15827577
|
ACROBiosystems
PV3-H52E4-1MG |
1 mg |
2612.85€
1mg |
Estimated Shipment: 08-05-2024
Log in to see stock. |
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Description
Poliovirus receptor-related 3 (PVRL3), also known as nectin-3 and CD113, is a human protein of the immunoglobulin superfamily which forms part of adherens junctions. Nectins are immunoglobulin-like adhesion molecules that interact with afadin (AF6; MIM 159559). Afadin is an actin filament-binding protein that connects nectins to the actin cytoskeleton. The nectin-afadin system organizes adherens junctions cooperatively with the cadherin system in epithelial cells. PVRL3 plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Furthermore, PVRL3 induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation.
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 39.6 kDa. The protein migrates as 55-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Specifications
| Q9NQS3 | |
| Human Nectin-3, His Tag (PV3-H52E4) is expressed from human 293 cells (HEK293). It contains AA Gly 58 - Asp 400 (Accession # Q9NQS3). | |
| -20°C | |
| Nectin-3 | |
| Human | |
| PBS, pH7.4 | |
| HEK293 | |
| Immune Checkpoint Proteins |
| 39.6 kDa | |
| Gly 58 - Asp 400 | |
| CD113,Nectin-3,PVRL3 | |
| Unconjugated | |
| His Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >95% as determined by SDS-PAGE |