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ACROBiosystems Human Integrin alpha 2b beta 3 (ITGAIIb&ITGB3) Heterodimer Protein, His Tag&Tag Free

Brand:  ACROBiosystems IT3-H52W8-1MG

Additional Details : Weight : 0.00001kg

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Product Code. 15807157

  • 2905.32€ / 1mg


Estimated Shipment: 22-10-2021
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Description

Description

Integrin alpha IIb beta 3 exist in a conformational equilibrium clustered around four main states. These conformations range from a compact bent nodule to two partially extended intermediate conformers and finally to a fully upright state. Activation of blood platelets by physiological stimuli at sites of vascular injury induces inside-out signaling, resulting in a conformational change of the prototype Integrin alpha IIb beta 3 from an inactive to an active state competent to bind soluble fibrinogen. Furthermore, ligand occupancy of Integrin alpha IIb beta 3 outside-in signaling and additional conformational changes of the receptor, leading to the exposure of extracellular neoepitopes termed ligand-induced binding sites (LIBS), which are recognized by anti-LIBS monoclonal antibodies.

Human ITGAIIb&ITGB3 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGAIIb and ITGB3, has a calculated MW of 111.4 kDa (ITGAIIb) and 81.8 kDa (ITGB3). Subunit ITGAIIb is fused with an acidic tail at the C-terminus and followed by a po
Specifications

Specifications

NP_000410.2 (R887L) (ITGAIIb) and AAI27667.1 (ITGB3)
HEK293
Human
111.4 kDa (ITGAIIb) and 81.8 kDa (ITGB3)
1 mg
Leu 32 - Arg 993 (ITGAIIb) and Gly 27 - Asp 718 (ITGB3)
Integrin alpha 2 b beta 3,ITGAIIbandITGB3
Unconjugated
50 mM Tris, 150 mM NaCl, pH7.5
Less than 1.0 EU / µg by the LAL method.
Bio-Markers and CD Antigens
Powder
>90% as determined by SDS-PAGE
Human ITGAIIb&ITGB3; Heterodimer Protein, His Tag&Tag; Free (IT3-H52W8) is expressed from human 293 cells (HEK293). It contains AA Leu 32 - Arg 993 (ITGAIIb) and Gly 27 - Asp 718 (ITGB3) (Accession # P08514-1 (R887L) (ITGAIIb) and P05106-1 (ITGB3)).
-20°C
Integrin alpha 2 b beta 3
His Tag
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