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ACROBiosystems Human Integrin alpha 2b beta 3 (ITGAIIb&ITGB3) Heterodimer Protein, His Tag&Tag Free
531.20€ - 4146.01€
Specifications
Accession Number | NP_000410.2 (R887L) (ITGAIIb) and AAI27667.1 (ITGB3) |
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Molecular Weight (g/mol) | 111.4 kDa (ITGAIIb) and 81.8 kDa (ITGB3) |
Source | Human ITGAIIb&ITGB3; Heterodimer Protein, His Tag&Tag; Free (IT3-H52W8) is expressed from human 293 cells (HEK293). It contains AA Leu 32 - Arg 993 (ITGAIIb) and Gly 27 - Asp 718 (ITGB3) (Accession # P08514-1 (R887L) (ITGAIIb) and P05106-1 (ITGB3)). |
Immunogen | Leu 32 - Arg 993 (ITGAIIb) and Gly 27 - Asp 718 (ITGB3) |
Storage Requirements | -20°C |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
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Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
15897147
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ACROBiosystems
IT3-H52W8-100UG |
100 μg |
531.20€
100µg |
Estimated Shipment: 11-04-2024
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15807157
|
ACROBiosystems
IT3-H52W8-1MG |
1 mg |
4146.01€
1mg |
Estimated Shipment: 11-04-2024
Log in to see stock. |
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Description
Integrin alpha IIb beta 3 exist in a conformational equilibrium clustered around four main states. These conformations range from a compact bent nodule to two partially extended intermediate conformers and finally to a fully upright state. Activation of blood platelets by physiological stimuli at sites of vascular injury induces inside-out signaling, resulting in a conformational change of the prototype Integrin alpha IIb beta 3 from an inactive to an active state competent to bind soluble fibrinogen. Furthermore, ligand occupancy of Integrin alpha IIb beta 3 outside-in signaling and additional conformational changes of the receptor, leading to the exposure of extracellular neoepitopes termed ligand-induced binding sites (LIBS), which are recognized by anti-LIBS monoclonal antibodies.
Human ITGAIIb&ITGB3 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGAIIb and ITGB3, has a calculated MW of 111.4 kDa (ITGAIIb) and 81.8 kDa (ITGB3). Subunit ITGAIIb is fused with an acidic tail at the C-terminus and followed by a poSpecifications
NP_000410.2 (R887L) (ITGAIIb) and AAI27667.1 (ITGB3) | |
Human ITGAIIb&ITGB3; Heterodimer Protein, His Tag&Tag; Free (IT3-H52W8) is expressed from human 293 cells (HEK293). It contains AA Leu 32 - Arg 993 (ITGAIIb) and Gly 27 - Asp 718 (ITGB3) (Accession # P08514-1 (R887L) (ITGAIIb) and P05106-1 (ITGB3)). | |
-20°C | |
Integrin alpha 2 b beta 3 | |
Human | |
50 mM Tris, 150 mM NaCl, pH7.5 | |
HEK293 | |
Bio-Markers and CD Antigens |
111.4 kDa (ITGAIIb) and 81.8 kDa (ITGB3) | |
Leu 32 - Arg 993 (ITGAIIb) and Gly 27 - Asp 718 (ITGB3) | |
Integrin alpha 2 b beta 3,ITGAIIbandITGB3 | |
Unconjugated | |
His Tag | |
Less than 1.0 EU / μg by the LAL method. | |
Powder | |
>90% as determined by SDS-PAGE |