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ACROBiosystems Human IL-10 Protein, His Tag
261.29€ - 522.57€
Specifications
Accession Number | NP_000563.1 |
---|---|
Molecular Weight (g/mol) | 19.5 kDa |
Source | Human IL-10, His Tag (IL0-H4248) is expressed from human 293 cells (HEK293). It contains AA Ser 19 - Asn 178 (Accession # NP_000563.1). |
Immunogen | Ser 19 - Asn 178 |
Storage Requirements | -20°C |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
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Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
15817017
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ACROBiosystems
IL0-H4248-50UG |
50 μg |
522.57€
50µg |
Estimated Shipment: 02-05-2024
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15807017
|
ACROBiosystems
IL0-H4248-20UG |
20 μg |
261.29€
20µg |
Estimated Shipment: 02-05-2024
Log in to see stock. |
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Description
Interleukin-10 (IL-10) is also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. IL-10 is an immunosuppressive cytokine produced by a variety of mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes. Mature human IL-10 shares 72% - 86% amino acid sequence identity with bovine, canine, equine, feline, mouse, ovine, porcine, and rat IL-10. Whereas human IL-10 is active on mouse cells, mouse IL-10 does not act on human cells. IL-10 is capable of inhibiting synthesis of pro-inflammatory cytokines such as IFN-γ, IL-2, IL-3, TNFα and GM-CSF made by cells such as macrophages and regulatory T-cells. It also displays a potent ability to suppress the antigen-presentation capacity of antigen presenting cells. However, it is also stimulatory towards certain T cells and mast cells and stimulates B cell maturation and antibody production. Knockout studies suggested the function of Interleukin-10 / IL-10 as an essential immunoregulator in the intestinal tract. Patients with Crohn's disease react favorably towards treatment with bacteria producing recombinant interleukin-10, showing the importance of interleukin-10 for counteracting excessive immunity in the human body.
This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 19.5 kDa. The protein migrates as 19 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Specifications
NP_000563.1 | |
Human IL-10, His Tag (IL0-H4248) is expressed from human 293 cells (HEK293). It contains AA Ser 19 - Asn 178 (Accession # NP_000563.1). | |
-20°C | |
IL-10 | |
Human | |
PBS, pH7.4 | |
HEK293 | |
Cytokines and Growth Factors |
19.5 kDa | |
Ser 19 - Asn 178 | |
CSIF,IL-10,IL10A,TGIF,B-TCGF,GVHDS,MGC126450,MGC126451,RP11-262N9.1,Interleukin-10 | |
Unconjugated | |
His Tag | |
Less than 1.0 EU / μg by the LAL method. | |
Powder | |
>95% as determined by SDS-PAGE |