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ACROBiosystems Human HVEM / TNFRSF14 Protein, Strep Tag

Brand:  ACROBiosystems HVM-H5283-250UG

Additional Details : Weight : 0.00001kg

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Product Code. 15806957

  • 887.74€ / 250µg


Estimated Shipment: 19-10-2021
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Description

Description

Herpesvirus entry mediator (HVEM) is also known as TNFRSF14, TR2 (TNF receptorlike molecule) and ATAR (another TRAF associated receptor), is a type I membrane protein belonging to the TNF/NGF receptor superfamily. HVEM expression has been detected in peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells. The extracellular domain of HVEM has been shown to interact directly with the herpes simplex virus envelope glycoprotein D (gD). Two TNF superfamily ligands, including the secreted TNFβ (lymphotoxin α) and the membrane protein LIGHT (lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes), have been shown to be the cellular ligands for HVEM. Besides HVEM, LIGHT can also interact with LTβR, the receptor for lymphotoxin αβ heterotrimer. The role of the HVEM LIGHT /LTβ receptor ligand pair in immune function and herpesvirus pathobiology remains to be elucidated.

This protein carries a twin strep tag at the C-terminus. The protein has a calculated MW of 20.4 kDa. The protein migrates as 27-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Specifications

Specifications

NP_003811.2
HEK293
Human
20.4 kDa
250 µg
Leu 39 - Val 202
TNFRSF14,ATAR,HVEA,HVEM,LIGHTR,TR2,CD270
Unconjugated
PBS, pH7.4
Less than 1.0 EU / µg by the LAL method.
Immune Checkpoint Proteins
Powder
>90% as determined by SDS-PAGE
Human HVEM, Strep Tag (HVM-H5283) is expressed from human 293 cells (HEK293). It contains AA Leu 39 - Val 202 (Accession # NP_003811.2).
-20°C
HVEM
Strep Tag
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