missing translation for 'onlineSavingsMsg'
Learn More

ACROBiosystems Human Gremlin / GREM1 Protein, Fc Tag

Brand:  ACROBiosystems GR1-H5254-100UG

Additional Details : Weight : 0.00001kg

 View more versions of this product

Product Code. 15826897

  • 401.64€ / 100µg
Estimated Shipment: 02-04-2024
to see stock.
Add to basket

Description

Description

Gremlin is also known as Cysteine knot superfamily 1, BMP antagonist 1 (CKTSF1B1), DAN domain family member 2 (DAND2), Down-regulated in Mos-transformed cells protein (DRM), Increased in high glucose protein 2 (IHG-2), Cell proliferation-inducing gene 2 protein (PIG2) or Gremlin-1 (GREM1), which is highly expressed in small intestine, fetal brain and colon. Gremlin / GREM-1 interacts with SLIT1 and SLIT2 in a glycosylation-dependent manner. Gremlin may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Gremlin down-regulates the BMP4 signaling in a dose-dependent manner and acts as inhibitor of monocyte chemotaxis.

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 44.2 kDa. The protein migrates as 48-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Specifications

Specifications

NP_037504
100 μg
Lys 25 - Asp 184
GREM1,CKTSF1B1,DAND2,DRM,PIG2
Unconjugated
Fc Tag
Less than 1.0 EU / μg by the LAL method.
Powder
>95% as determined by SDS-PAGE
44.2 kDa
Human Gremlin, Fc Tag (GR1-H5254) is expressed from human 293 cells (HEK293). It contains AA Lys 25 - Asp 184 (Accession # NP_037504).
-20°C
Gremlin
Human
50 mM Tris, 150 mM NaCl, pH7.5 with 1 mM EDTA
HEK293
Cytokines and Growth Factors
Product Suggestions

Product Suggestions

Videos
SDS
Documents

Documents

Certificates
Special Offers

Special Offers