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ACROBiosystems Human Gremlin / GREM1 Protein, Fc Tag

Brand:  ACROBiosystems GR1-H5254-100UG

Additional Details : Weight : 0.00001kg

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Product Code. 15826897

  • 312.72€ / 100µg


Estimated Shipment: 20-10-2021
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Description

Description

Gremlin is also known as Cysteine knot superfamily 1, BMP antagonist 1 (CKTSF1B1), DAN domain family member 2 (DAND2), Down-regulated in Mos-transformed cells protein (DRM), Increased in high glucose protein 2 (IHG-2), Cell proliferation-inducing gene 2 protein (PIG2) or Gremlin-1 (GREM1), which is highly expressed in small intestine, fetal brain and colon. Gremlin / GREM-1 interacts with SLIT1 and SLIT2 in a glycosylation-dependent manner. Gremlin may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Gremlin down-regulates the BMP4 signaling in a dose-dependent manner and acts as inhibitor of monocyte chemotaxis.

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 44.2 kDa. The protein migrates as 48-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Specifications

Specifications

NP_037504
HEK293
Human
44.2 kDa
100 µg
Lys 25 - Asp 184
GREM1,CKTSF1B1,DAND2,DRM,PIG2
Unconjugated
50 mM Tris, 150 mM NaCl, pH7.5 with 1 mM EDTA
Less than 1.0 EU / µg by the LAL method.
Cytokines and Growth Factors
Powder
>95% as determined by SDS-PAGE
Human Gremlin, Fc Tag (GR1-H5254) is expressed from human 293 cells (HEK293). It contains AA Lys 25 - Asp 184 (Accession # NP_037504).
-20°C
Gremlin
Fc Tag
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