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ACROBiosystems Human CTLA-4 / CD152 Protein, His Tag
182.90€ - 1306.42€
Specifications
Accession Number | NP_005205.2 |
---|---|
Molecular Weight (g/mol) | 15.4 kDa |
Source | Human CTLA-4, His Tag (CT4-H5229) is expressed from human 293 cells (HEK293). It contains AA Ala 37 - Phe 162 (Accession # NP_005205.2). |
Immunogen | Ala 37 - Phe 162 |
Storage Requirements | -20°C |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
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Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
15826517
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ACROBiosystems
CT4-H5229-1MG |
1 mg |
1306.42€
1mg |
Estimated Shipment: 07-05-2024
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15816517
|
ACROBiosystems
CT4-H5229-100UG |
100 μg |
182.90€
100µg |
Estimated Shipment: 07-05-2024
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Description
CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. T cell activation through the T cell receptor and CD28 leads to increased expression of CTLA-4, an inhibitory receptor for B7 molecules. Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis.
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 15.4 kDa. The protein migrates as 20-25 kDa under reducing (R) condition (SDS-PAGE) due to different extent glycosylation.Specifications
NP_005205.2 | |
Human CTLA-4, His Tag (CT4-H5229) is expressed from human 293 cells (HEK293). It contains AA Ala 37 - Phe 162 (Accession # NP_005205.2). | |
-20°C | |
CTLA-4 | |
Human | |
PBS, pH7.4 | |
HEK293 | |
Immune Checkpoint Proteins |
15.4 kDa | |
Ala 37 - Phe 162 | |
CTLA4,CD152 | |
Unconjugated | |
His Tag | |
Less than 1.0 EU / μg by the LAL method. | |
Powder | |
>95% as determined by SDS-PAGE |