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ACROBiosystems Human COMP / TSP5 Protein, His Tag

Brand:  ACROBiosystems COP-H5220-100UG

Additional Details : Weight : 0.00001kg

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Product Code. 15826467

  • 252.20€ / 100µg


Estimated Shipment: 19-10-2021
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Description

Description

Cartilage oligomeric matrix protein (COMP) is also known as Thrombospondin-5 (TSP5), EDM1, EPD1, MED, PSACH, THBS5, which belongs to the thrombospondin family. COMP / TSP5 contains 4 EGF-like domains, 1 TSP C-terminal (TSPC) domain, 8 TSP type-3 repeats. Abundantly expressed in the chondrocyte extracellular matrix, and is also found in bone, tendon, ligament and synovium and blood vessels. COMP may play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. COMP can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Thrombospondin-5 could play a role in the pathogenesis of osteoarthritis. COMP is a marker of cartilage turnover.

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 81.9 kDa. The protein migrates as 110-130 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Specifications

Specifications

AAI25093
HEK293
Human
81.9 kDa
100 µg
Gln 21 - Ala 757
COMP,TSP5,EDM1,EPD1,MED,PSACH,THBS5
Unconjugated
50 mM Tris, 150 mM NaCl, pH7.5
Less than 1.0 EU / µg by the LAL method.
Bio-Markers and CD Antigens
Powder
>88% as determined by SDS-PAGE
Human COMP, His Tag (COP-H5220) is expressed from human 293 cells (HEK293). It contains AA Gln 21 - Ala 757 (Accession # AAI25093).
-20°C
COMP
His Tag
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