missing translation for 'onlineSavingsMsg'
Learn More

ACROBiosystems Human CD96 / TACTILE Protein, Mouse IgG2a Fc Tag, low endotoxin

low endotoxin

453.47€ - 3329.77€

Specifications

Accession Number NP_005807.1
Molecular Weight (g/mol) 80.4 kDa
Source Human CD96, Mouse IgG2a Fc Tag, low endotoxin (TAE-H5252) is expressed from human 293 cells (HEK293). It contains AA Val 22 - Met 503 (Accession # P40200-2).
Immunogen Val 22 - Met 503
Storage Requirements -20°C
View More Specs

Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15897727
View Documents Promotion Details
ACROBiosystems
TAE-H5252-100UG
100 μg
453.47€
100µg
View alternative products
Save Up to 
»
Estimated Shipment: 11-04-2024
to see stock.
Add to basket
 
15807737
View Documents Promotion Details
ACROBiosystems
TAE-H5252-1MG
1 mg
3329.77€
1mg
View alternative products
Save Up to 
»
Estimated Shipment: 11-04-2024
to see stock.
Add to basket
 
Description

Description

The progression of pancreatic cancer (PC) is significantly associated with tumor immune escape, which may be associated with nature killer (NK) cell dysfunction. CD226, CD96, and TIGIT, which share the ligand CD155, play important roles in the regulation of NK cell function. The present study was conducted to investigate the roles of these molecules in NK cells from PC patients. TIGIT and CD96 together with the co-stimulatory receptor CD226 form a pathway that is analogous to the CD28/CTLA-4 pathway, in which shared ligands and differential receptor:ligand affinities fine-tune the immune response. Although the roles of TIGIT and CD96 as immune checkpoint receptors in T cell and natural killer cell biology are just beginning to be uncovered, accumulating data support the targeting of these receptors for improving anti-tumor immune responses. A clear understanding of the immune cell populations regulated by TIGIT and CD96 is key to the design of immunotherapies that target these receptors in combination with other existing immune checkpoint blockade therapies. The dysfunction of CD96 may trigger C syndrome: A syndrome characterized by trigonocephaly, severe mental retardation, hypotonia, variable cardiac defects, redundant skin, and dysmorphic facial features, including upslanted palpebral fissures, epicanthal folds, depressed nasal bridge, and low-set, posteriorly rotated ears.

This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 80.4 kDa. The protein migrates as 110-130 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Specifications

Specifications

NP_005807.1
Human CD96, Mouse IgG2a Fc Tag, low endotoxin (TAE-H5252) is expressed from human 293 cells (HEK293). It contains AA Val 22 - Met 503 (Accession # P40200-2).
-20°C
CD96
Human
Tris with Glycine, Arginine and NaCl, pH7.5
HEK293
Immune Checkpoint Proteins
80.4 kDa
Val 22 - Met 503
TACTILE
Unconjugated
Mouse IgG Fc Tag
Less than 0.1 EU / μg by the LAL method.
Powder
>90% as determined by reduced SDS-PAGE
Videos
SDS
Documents

Documents

Product Certifications