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ACROBiosystems Human B7-H4 Protein, His Tag

Brand:  ACROBiosystems B74-H5222-1MG

Additional Details : Weight : 0.00001kg

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Product Code. 15815967

  • 1513.19€ / 1mg


Estimated Shipment: 22-10-2021
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Description

Description

V-set domain-containing T-cell activation inhibitor 1 (VTCN1) is also known as Immune costimulatory protein B7-H4, Protein B7S1, T-cell costimulatory molecule B7x, B7H4, which belongs to the immunoglobulin superfamily and BTN/MOG family. VTCN1 contains two Ig-like V-type (immunoglobulin-like) domains. The expression of VTCN1 is up-regulated by IL6 and IL10 and is inhibited by GM-CSF and IL4 on antigen-presenting cells (APCs). VTCN1 / B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. VTCN1 involved in promoting epithelial cell transformation.

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 26.4 kDa. The protein migrates as 43-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Specifications

Specifications

NP_078902
HEK293
Human
26.4 kDa
1 mg
Phe 29 - Ala 258
B7-H4,VTCN1,B7S1,B7h0.5
Unconjugated
PBS, pH7.4
Less than 1.0 EU / µg by the LAL method.
Immune Checkpoint Proteins
Powder
>95% as determined by SDS-PAGE
Human B7-H4, His Tag (B74-H5222) is expressed from human 293 cells (HEK293). It contains AA Phe 29 - Ala 258 (Accession # NP_078902).
-20°C
B7-H4
His Tag
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