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ACROBiosystems Human B7-1 / CD80 Protein, Fc Tag

HPLC-verified

Brand:  ACROBiosystems B71-H5259-1MG

Additional Details : Weight : 0.00001kg

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Product Code. 15815947

  • 1775.47€ / 1mg


Estimated Shipment: 22-10-2021
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Description

Description

B7­1 and B7­2, together with their receptors CD28 and CTLA­4, constitute one of the dominant co-stimulatory pathways that regulate T­ and B­cell responses. Although both CTLA­4 and CD28 can bind to the same ligands, CTLA­4 binds to B7­1 and B7­2 with a 20 ­ 100 fold higher affinity than CD28 and is involved in the down­regulation of the immune response. B-lymphocyte activation antigen B7-1 (referred to as B7) also known as cluster of Differentiation 80 (CD80), is a member of cell surface immunoglobulin superfamily and is expressed on activated B cells, activated T cells, macrophages and dendritic cells. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD80 works in tandem with CD86 to prime T cells. CD80 plays a role in induction of innate immune responses by activating NF-κB-signaling pathway in macrophages. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 50.0 kDa. The protein migrates as 65-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Specifications

Specifications

NP_005182.1
HEK293
Human
50.0 kDa
1 mg
Val 35 - Asn 242
CD80,B7,B7-1,B7.1,BB1,CD28LG,CD28LG1,LAB7
Unconjugated
50 mM Tris, 100 mM Glycine, pH7.5
Less than 1.0 EU / µg by the LAL method.
Immune Checkpoint Proteins
Powder
>95% as determined by SDS-PAGE
Human B7-1, Fc Tag (HPLC-verified) (B71-H5259) is expressed from human 293 cells (HEK293). It contains AA Val 35 - Asn 242 (Accession # NP_005182.1).
-20°C
B7-1
Fc Tag
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