missing translation for 'onlineSavingsMsg'
Learn More

ACROBiosystems Hamster PCSK9 Protein, His Tag

Brand:  ACROBiosystems PC9-H52E4-1MG

Additional Details : Weight : 0.00001kg

 View more versions of this product

Product Code. 15817437

  • 1997.41€ / 1mg


Estimated Shipment: 20-10-2021
Add to basket

Description

Description

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is also known as NARC1 (neural apoptosis regulated convertase), is a newly identified subtilase belonging to the peptidase S8 subfamily. Mouse PCSK9 is synthesized as a soluble zymogen, and undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted active enzyme with a broad alkaline pH optimum. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3).

This protein carries a polyhistidine tag at the C-terminus. This protein undergoes autocatalytic cleavage to release the pro-peptide and mature chain. The pro-peptide and mature chain are associated through non‐covalent interactions and with a calculated
Specifications

Specifications

Less than 1.0 EU / µg by the LAL method.
Bio-Markers and CD Antigens
Powder
>95% as determined by SDS-PAGE
Hamster PCSK9, His Tag (PC9-H52E4) is expressed from human 293 cells (HEK293). It contains AA Gln 30 - Ser 691 (Accession # G3GTK5).
-20°C
PCSK9
His Tag
HEK293
Hamster
13.9 kDa and 59.0 kDa
1 mg
Gln 30 - Ser 691
PCSK9,FH3,HCHOLA3,LDLCQ1,NARC1,PC9
Unconjugated
PBS, pH7.4
Videos
SDS
Documents
Certificates