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ACROBiosystems Ebolavirus BDBV (subtype Bundibugyo, strain Uganda 2007) Small/secreted Glycoprotein (sGP) Protein, His Tag
375.73€ - 3161.34€
Specifications
Molecular Weight (g/mol) | 34.3 kDa |
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Source | Ebolavirus BDBV (subtype Bundibugyo, strain Uganda 2007) sGP, His Tag (BEP-V5220) is expressed from human 293 cells (HEK293). It contains AA Ile 33 - Arg 324 (Accession # B8XCN1). |
Immunogen | Ile 33 - Arg 324 |
Storage Requirements | -20°C |
Gene Alias | GP,Envelope glycoprotein,GP(1,2) |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
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Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
15806047
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ACROBiosystems
BEP-V5220-1MG |
1 mg |
3161.34€
1mg |
Estimated Shipment: 11-04-2024
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15816047
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ACROBiosystems
BEP-V5220-50UG |
50 μg |
375.73€
50µg |
Estimated Shipment: 11-04-2024
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Description
EBOV encodes seven structural proteins: nucleoprotein (NP), polymerase cofactor (VP35), (VP40), GP, transcription activator (VP30), VP24, and RNA polymerase (L). GP protein contains 160-kDa envelope-attached glycoprotein (GP) and a 110 kDa secreted glycoprotein (sGP). GP is a class I fusion protein which assembles as trimers on viral surface and plays an important role in virus entry and attachment. Mature GP is a disulfide-linked heterodimer formed by two subunits, GP1 and GP2, which are generated from the proteolytical process of GP precursor (pre-GP) by cellular furin during virus assembly . GP1 is responsible for binding to the receptor(s) on target cells. Interacts with CD209/DC-SIGN and CLEC4M/DC-SIGNR which act as cofactors for virus entry into the host cell. GP2 acts as a class I viral fusion protein. GP1,2 mediates endothelial cell activation and decreases endothelial barrier function. sGP seems to possess an anti-inflammatory activity as it can reverse the barrier-decreasing effects of TNF alpha.
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 34.3 kDa. The protein migrates as 45-55 kDa under reducing (R) condition (SDS-PAGE).Specifications
34.3 kDa | |
Ile 33 - Arg 324 | |
GP,Envelope glycoprotein,GP(1,2) | |
Unconjugated | |
His Tag | |
Less than 1.0 EU / μg by the LAL method. | |
Powder | |
>95% as determined by SDS-PAGE |
Ebolavirus BDBV (subtype Bundibugyo, strain Uganda 2007) sGP, His Tag (BEP-V5220) is expressed from human 293 cells (HEK293). It contains AA Ile 33 - Arg 324 (Accession # B8XCN1). | |
-20°C | |
Glycoprotein / GP (virus) | |
Ebolavirus | |
PBS, pH7.4 | |
HEK293 | |
Viral Proteins |