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ACROBiosystems Ebolavirus BDBV (subtype Bundibugyo, strain Uganda 2007) Small/secreted Glycoprotein (sGP) Protein, His Tag

Brand:  ACROBiosystems BEP-V5220-50UG

Additional Details : Weight : 0.00001kg

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Product Code. 15816047

  • 292.55€ / 50µg


Estimated Shipment: 26-10-2021
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Description

Description

EBOV encodes seven structural proteins: nucleoprotein (NP), polymerase cofactor (VP35), (VP40), GP, transcription activator (VP30), VP24, and RNA polymerase (L). GP protein contains 160-kDa envelope-attached glycoprotein (GP) and a 110 kDa secreted glycoprotein (sGP). GP is a class I fusion protein which assembles as trimers on viral surface and plays an important role in virus entry and attachment. Mature GP is a disulfide-linked heterodimer formed by two subunits, GP1 and GP2, which are generated from the proteolytical process of GP precursor (pre-GP) by cellular furin during virus assembly . GP1 is responsible for binding to the receptor(s) on target cells. Interacts with CD209/DC-SIGN and CLEC4M/DC-SIGNR which act as cofactors for virus entry into the host cell. GP2 acts as a class I viral fusion protein. GP1,2 mediates endothelial cell activation and decreases endothelial barrier function. sGP seems to possess an anti-inflammatory activity as it can reverse the barrier-decreasing effects of TNF alpha.

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 34.3 kDa. The protein migrates as 45-55 kDa under reducing (R) condition (SDS-PAGE).
Specifications

Specifications

Less than 1.0 EU / µg by the LAL method.
Viral Proteins
Powder
>95% as determined by SDS-PAGE
Ebolavirus BDBV (subtype Bundibugyo, strain Uganda 2007) sGP, His Tag (BEP-V5220) is expressed from human 293 cells (HEK293). It contains AA Ile 33 - Arg 324 (Accession # B8XCN1).
-20°C
Glycoprotein / GP (virus)
His Tag
HEK293
Ebolavirus
34.3 kDa
50 µg
Ile 33 - Arg 324
GP,Envelope glycoprotein,GP(1,2)
Unconjugated
PBS, pH7.4
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