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ACROBiosystems Cynomolgus / Rhesus macaque IL-4 R alpha / CD124 Protein, His Tag

Brand:  ACROBiosystems ILR-C52H8-1MG

Additional Details : Weight : 0.00001kg

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Product Code. 15827117

  • 1997.41€ / 1mg


Estimated Shipment: 29-10-2021
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Description

Description

IL-4 is a pleiotropic cytokine produced by activated Th2 cells and mast cells, and plays a pivotal role in immune responses. The effects of IL-4 are mediated after binding to high affinity receptor complexes present on hematopoietic as well as non-hematopoietic cells. Hematopoietic cellular responses to IL-4 are mediated by a high affinity receptor complex comprised of the 140 kDa IL4Rα (CD124)subunit and the 70 kDa common cytokine γc chain (CD132). Interleukin 4 Receptor (IL4R) also known as CD124, IL4Rα and BSF receptor, is a type I cytokine receptor produced by activated Th2 cells and mast cells, and plays an important role in Th2-­biased immune responses, alternative macrophage activation, mucosal immunity, allergic inflammation, tumor progression, and atherogenesis. A soluble form of the encoded IL4R protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. IL4R can alternatively associate with IL­13Ra1 to form the type II receptor which is responsive to both IL­4 and IL­13. Interleukin-4 receptor has been shown to interact with SHC1.

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 25.6 kDa. The protein migrates as 40-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Specifications

Specifications

Less than 1.0 EU / µg by the LAL method.
Bio-Markers and CD Antigens
Powder
>95% as determined by SDS-PAGE
Cynomolgus / Rhesus macaque IL-4 R alpha, His Tag (ILR-C52H8) is expressed from human 293 cells (HEK293). It contains AA Met 26 - Arg 232 (Accession # G7Q0S7). In the region Met 26 - Arg 232, the AA sequence of Cynomolgus and Rhesus macaque IL-4 R alpha are homologus.
-20°C
IL-4 R alpha
His Tag
HEK293
Cynomolgus / Rhesus macaque
25.6 kDa
1 mg
Met 26 - Arg 232
IL4R,CD124,IL4RA
Unconjugated
PBS, pH7.4
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