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ACROBiosystems Cynomolgus / Rhesus macaque 4-1BB / TNFRSF9 Protein, His Tag

MALS verified

Brand:  ACROBiosystems 41B-C52H4-100UG

Additional Details : Weight : 0.00001kg

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Product Code. 15815857

  • 353.08€ / 100µg


Estimated Shipment: 26-10-2021
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Description

Description

4-1BB is also known as CD137, tumor necrosis factor receptor superfamily member 9 (TNFRSF9), induced by lymphocyte activation (ILA), is a co-stimulatory molecule of the tumor necrosis factor (TNF) receptor superfamily. CD137 can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, CD137 expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation. The best characterized activity of CD137 is its costimulatory activity for activated T cells. Crosslinking of CD137 enhances T cell proliferation, IL-2 secretion survival and cytolytic activity. Further, it can enhance immune activity to eliminate tumors in mice. CD137 can enhance activation-induced T cell apoptosis when triggered by engagement of the TCR/CD3 complex. In addition, 4-1BB/4-1BBL co-stimulatory pathway has been shown to augment secondary CTL responses to several viruses, and meanwhile augment anti-tumor immunity. 4-1BB thus is a promising candidate for immunotherapy of human cancer. CD137 has been shown to interact with TRAF2.

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 19.2 kDa. The protein migrates as 30-40 kDa under reducing (R) condition (SDS-PAGE).
Specifications

Specifications

XP_005544945.1
HEK293
Cynomolgus / Rhesus macaque
19.2 kDa
100 µg
Leu 24 - Gln 186
TNFRSF9,4-1 BB,CD137,CDw137,ILA
Unconjugated
PBS, pH7.4
Less than 1.0 EU / µg by the LAL method.
Immune Checkpoint Proteins
Powder
>92% as determined by SDS-PAGE
Cynomolgus / Rhesus macaque 4-1 BB, His Tag (41 B-C52H4) is expressed from human 293 cells (HEK293). It contains AA Leu 24 - Gln 186 (Accession # XP_005544945.1). In the region Leu 24 - Gln 186, the AA sequence of Cynomolgus and Rhesus macaque 4-1 BB are homologus.
-20°C
4-1 BB
His Tag
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