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ACROBiosystems Cynomolgus / Rhesus macaque 4-1BB / TNFRSF9 Protein, His Tag
MALS verified
453.47€ - 2850.38€
Specifications
Accession Number | XP_005544945.1 |
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Molecular Weight (g/mol) | 19.2 kDa |
Source | Cynomolgus / Rhesus macaque 4-1 BB, His Tag (41 B-C52H4) is expressed from human 293 cells (HEK293). It contains AA Leu 24 - Gln 186 (Accession # XP_005544945.1). In the region Leu 24 - Gln 186, the AA sequence of Cynomolgus and Rhesus macaque 4-1 BB are homologus. |
Immunogen | Leu 24 - Gln 186 |
Storage Requirements | -20°C |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
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Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
15825857
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ACROBiosystems
41B-C52H4-1MG |
1 mg |
2850.38€
1mg |
Estimated Shipment: 11-04-2024
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15815857
|
ACROBiosystems
41B-C52H4-100UG |
100 μg |
453.47€
100µg |
Estimated Shipment: 11-04-2024
Log in to see stock. |
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Description
4-1BB is also known as CD137, tumor necrosis factor receptor superfamily member 9 (TNFRSF9), induced by lymphocyte activation (ILA), is a co-stimulatory molecule of the tumor necrosis factor (TNF) receptor superfamily. CD137 can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, CD137 expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation. The best characterized activity of CD137 is its costimulatory activity for activated T cells. Crosslinking of CD137 enhances T cell proliferation, IL-2 secretion survival and cytolytic activity. Further, it can enhance immune activity to eliminate tumors in mice. CD137 can enhance activation-induced T cell apoptosis when triggered by engagement of the TCR/CD3 complex. In addition, 4-1BB/4-1BBL co-stimulatory pathway has been shown to augment secondary CTL responses to several viruses, and meanwhile augment anti-tumor immunity. 4-1BB thus is a promising candidate for immunotherapy of human cancer. CD137 has been shown to interact with TRAF2.
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 19.2 kDa. The protein migrates as 30-40 kDa under reducing (R) condition (SDS-PAGE).Specifications
XP_005544945.1 | |
Cynomolgus / Rhesus macaque 4-1 BB, His Tag (41 B-C52H4) is expressed from human 293 cells (HEK293). It contains AA Leu 24 - Gln 186 (Accession # XP_005544945.1). In the region Leu 24 - Gln 186, the AA sequence of Cynomolgus and Rhesus macaque 4-1 BB are homologus. | |
-20°C | |
4-1 BB | |
Cynomolgus Monkey, Rhesus Macaque | |
PBS, pH7.4 | |
HEK293 | |
Immune Checkpoint Proteins |
19.2 kDa | |
Leu 24 - Gln 186 | |
TNFRSF9,4-1 BB,CD137,CDw137,ILA | |
Unconjugated | |
His Tag | |
Less than 1.0 EU / μg by the LAL method. | |
Powder | |
>92% as determined by SDS-PAGE |