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ACROBiosystems Cynomolgus CRTAM Protein, Fc Tag

Brand:  ACROBiosystems CRM-C5255-100UG

Additional Details : Weight : 0.00001kg

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Product Code. 15816477

  • 292.55€ / 100µg


Estimated Shipment: 28-10-2021
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Description

Description

Class I-restricted T cell-associated molecule (CRTAM), a member of nectin family and the immunoglobulin superfamily, is also known as cytotoxic and regulatory T-cell molecule, which is expressed by activated CD8+ and NK T cells. CRTAM is found in spleen, thymus, small intestine, peripheral blood, and surprisingly, in brain where it is highly expressed by Purkinje cells of the cerebellum. The high affinity of CRTAM/IGSF4 adhesion allows CRTAM to disrupt IGSF4 homotypic interactions (3 - 5). IGSF4 and T cell receptor co-engagement of CRTAM-expressing CD8+ cells induces increased IFN-gamma or IL-22 production (3, 4). Furthermore, a role in cancer surveillance through NK cell-mediated rejection of IGSF4-expressing tumors has been proposed.

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 56.6 kDa. The protein migrates as 66-95 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Specifications

Specifications

XP_005580021.1
HEK293
Cynomolgus
56.6 kDa
100 µg
Ser 18 - Gly 287
CRTAM,CD355
Unconjugated
Tris with Glycine, Arginine and NaCl, pH7.5
Less than 1.0 EU / µg by the LAL method.
Other Recombinant Proteins
Powder
>90% as determined by SDS-PAGE
Cynomolgus CRTAM, Fc Tag (CRM-C5255) is expressed from human 293 cells (HEK293). It contains AA Ser 18 - Gly 287 (Accession # XP_005580021.1).
-20°C
CRTAM
Fc Tag
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