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CD161 Mouse anti-Human, PE, Clone: DX12, BD
Mouse Monoclonal Antibody
715.00€ - 1025.00€
Specifications
| Antigen | CD161 |
|---|---|
| Clone | DX12 |
| Applications | Flow Cytometry |
| Classification | Monoclonal |
| Conjugate | PE |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
15895908
|
BD Biosciences
340530 |
50 Tests |
1025.00€
Each |
Estimated Shipment: 21-05-2024
Log in to see stock. |
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|
15818638
|
BD Biosciences
556081 |
100 Tests |
715.00€
Each |
Estimated Shipment: 21-05-2024
Log in to see stock. |
|||||
Description
The DX12 monoclonal antibody specifically binds to human CD161 which is also known as Natural killer cell surface protein P1A (NKR-P1A). CD161 is encoded by the KLRB1 (Killer cell lectin-like receptor subfamily B member 1) gene. CD161 is a member of the C-type lectin superfamily and is also referred to as C-type lectin domain family 5 member B (CLEC5B). CD161 is a 80 kDa disulfide-linked homodimer, type II membrane glycoprotein. CD161 is expressed mostly on NK cell populations and on subsets of CD4+ and CD8+ αβ T cells, NKT cells and γδ T cells. Reports indicate that CD161 is expressed preferentially on CD45RO+ T cells, however, it can be found on a subset of thymocytes and fetal liver T cells. Its function has not been fully elucidated, but reports indicate that NKR-P1A may serve as a specific receptor for some NK cell targets. The DX12 antibody can reportedly inhibit spontaneous cytotoxicity mediated by certain NK cell clones.
Specifications
| CD161 | |
| Flow Cytometry | |
| PE | |
| RUO | |
| Human | |
| IgG1 κ |
| DX12 | |
| Monoclonal | |
| Mouse | |
| Immunology | |
| Human NKR-P1A Transfected Mouse Fibroblasts | |
| Primary |
For Research Use Only.