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CD16 Mouse anti-Human, Brilliant Violet 650, Clone: 3G8, BD
Mouse Monoclonal Antibody
361.00€ - 660.00€
Specifications
| Antigen | CD16 |
|---|---|
| Clone | 3G8 |
| Applications | Flow Cytometry |
| Classification | Monoclonal |
| Conjugate | Brilliant Violet 650 |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
15813009
|
BD Biosciences
563691 |
25 Tests |
361.00€
Each |
Estimated Shipment: 14-05-2024
Log in to see stock. |
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|
15823009
|
BD Biosciences
563692 |
100 Tests |
660.00€
Each |
Estimated Shipment: 03-05-2024
Log in to see stock. |
|||||
Description
The 3G8 monoclonal antibody specifically binds to the 50-65 kDa transmembrane form of the IgG Fc Receptor (Fc γRIII), a human NK cell-associated antigen. CD16 is expressed on NK cells as well as macrophages and granulocytes. Reports indicate that CD16 plays a role in signal transduction and NK cell activation. The 3G8 antibody blocks the binding of soluble immune complexes to granulocytes. The 3G8 antibody is reported (Vossebeld et al ., 1997) to increase intracellular calcium levels in human neutrophils by interacting with both Fc γRIIa and Fc γRIIIb molecules. This antibody has also been reported to induce homotypic neutrophil aggregation.
The antibody was conjugated to BD Horizon™ BV650 which is part of the BD Horizon™ Brilliant Violet™ family of dyes. This dye is a tandem fluorochrome of BD Horizon™ BV421 with an Ex Max of 405-nm and an acceptor dye with an Em Max at 650-nm. BD Horizon™ BV650 can be excited by the violet laser and detected in a filter used to detect APC-like dyes (eg, 660/20-nm filter). Due to the excitation and emission characteristics of the acceptor dye, there will be spillover into the APC and Alexa Fluor™ 700 detectors. However, the spillover can be corrected through compensation as with any other dye combination.
Specifications
| CD16 | |
| Flow Cytometry | |
| Brilliant Violet 650 | |
| RUO | |
| Human polymorphonuclear leukocytes | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
| 3G8 | |
| Monoclonal | |
| Mouse | |
| Baboon, Cynomolgus, Human, Rhesus Monkey | |
| IgG1 κ | |
| Affinity Purified | |
| FcRIII; Fc-gamma RIII; FCG3; FCGR3; FCGRIII; FcγRIII; IGFR3 |
For Research Use Only.