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CD154 Hamster anti-Mouse, PE, Clone: MR1, BD

Hamster Monoclonal Antibody

157.00€ - 447.00€

Specifications

Antigen CD154
Clone MR1
Concentration 0.2mg/mL
Applications Flow Cytometry
Classification Monoclonal
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15841269
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BD Biosciences
561719
25 μg
157.00€
Each
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Estimated Shipment: 23-04-2024
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15817328
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BD Biosciences
553658
0.2 mg
447.00€
Each
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Estimated Shipment: 23-04-2024
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Description

Description

The MR1 antibody reacts with CD154 (CD40 Ligand, gp39), an accessory molecule expressed on activated T helper (CD4+) lymphocytes. CD154 has also been detected on other types of leukocytes, including CD8+ T cells, medullary thymocytes, activated CD4+ NK-T cells, and human NK cells. CD154 plays an important role in costimulatory interactions between T and B lymphocytes and between antigen-presenting cells and lymphocytes, regulating the immune response at multiple levels. MR1 mAb inhibits in vitro activation of B lymphocytes by T helper cells by blocking interaction of gp39 with CD40. In vitro interactions of T cells and antigen-presenting cells can also be blocked by the MR1 antibody. In vivo treatment with MR1 antibody blocks the development of experimental autoimmune disease, inhibits formation of germinal centers and generation of memory B cells, reduces T-lymphocyte responses to allogeneic cells and allografts, prevents intrathymic deletion of self-reactive T lymphocytes, and disrupts antigen-specific T-cell responses.

Specifications

Specifications

CD154
0.2mg/mL
Monoclonal
Hamster
Mouse
Activated mouse Th1 clone D1.6
Affinity Purified
CD40 Ligand, gp39
MR1
Flow Cytometry
PE
RUO
Aqueous buffered solution containing ≤0.09% sodium azide.
Primary
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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