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ACROBiosystems Biotinylated Human LAIR1 / CD305 Protein, His, Avitag™

Biotinylated Protein

Brand:  ACROBiosystems LA1-H82E3-25UG

Additional Details : Weight : 0.00001kg

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Product Code. 15817207

  • 353.08€ / 25µg


Estimated Shipment: 22-10-2021
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Description

Description

Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is constitutively expressed on the majority of human peripheral blood mononuclear leukocytes. LAIR-1 or CD305 is a transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs. LAIR-1 recruits SHP-1 and SHP-2 phosphatases upon activation, and cross-linking of the LAIR-1 antigen on natural killer (NK) cells results in strong inhibition of NK cell–mediated cytotoxicity. Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation.Diseases associated with LAIR1 include Chronic Active Epstein-Barr Virus Infection and Palindromic Rheumatism.

This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag. The protein has a calculated MW of 19.2 kDa. The protein migrates as 30-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Specifications

Specifications

AAH27899.1
HEK293
Human
19.2 kDa
25 µg
Gln 22 - His 163
LAIR1,CD305
Precision Avi
PBS, pH7.4
Less than 1.0 EU / µg by the LAL method.
MABSol™ Biotin Labeled Proteins
Powder
>95% as determined by SDS-PAGE
Biotinylated Human LAIR-1, His,Avitag (LA1-H82E3) is expressed from human 293 cells (HEK293). It contains AA Gln 22 - His 163 (Accession # Q6GT x 8-1).
-20°C
LAIR-1
His Tag and Avi Tag
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