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ACROBiosystems Biotinylated Human IL-21 Protein, Fc,Avitag™
MALS verified
457.25€ - 2011.89€
Specifications
Accession Number | NP_001193935.1 |
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Molecular Weight (g/mol) | 43.6 kDa |
Source | Biotinylated Human IL-21, Fc,Avitag (IL1-H82F7) is expressed from human 293 cells (HEK293). It contains AA Gln 30 - Ser 162 (Accession # Q9HBE4-1). |
Immunogen | Gln 30 - Ser 162 |
Storage Requirements | -20°C |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
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Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
15837027
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ACROBiosystems
IL1-H82F7-25UG |
25 μg |
457.25€
25µg |
Estimated Shipment: 29-04-2024
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15827027
|
ACROBiosystems
IL1-H82F7-200UG |
200 μg |
2011.89€
200µg |
Estimated Shipment: 29-04-2024
Log in to see stock. |
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Description
Interleukin-21 (IL-21) is a secreted protein which belongs to the IL-15 / IL-21 family. Interleukin-21 / IL-21 belongs to a family of cytokines that bind to a composite receptor consisting of a private receptor (IL21R) and the common cytokine receptor gamma chain (gamma(C)). Interleukin-21 / IL-21 impacts a number of cell types, including CD8+ memory T cells, NK cells and subsets of CD4 memory T cells. The IL-21R is widely distributed on lympho-haematopoietic cells. IL-21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. Its action generally enhances antigen-specific responses of immune cells. IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the γ chain (γc) found in other cytokine receptors including IL-2, IL-4, IL-7, IL-9 and IL-15. The IL-21/IL-21R interaction triggers a cascade of events which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3.
This protein carries a human IgG1 Fc tag at the C-terminus, followed by a Avi tag (Avitag™). The protein has a calculated MW of 43.6 kDa. The protein migrates as 50-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Specifications
NP_001193935.1 | |
Biotinylated Human IL-21, Fc,Avitag (IL1-H82F7) is expressed from human 293 cells (HEK293). It contains AA Gln 30 - Ser 162 (Accession # Q9HBE4-1). | |
-20°C | |
IL-21 | |
Human | |
50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5 | |
HEK293 | |
MABSol™ Biotin Labeled Proteins |
43.6 kDa | |
Gln 30 - Ser 162 | |
IL21,Za11,Interleukin-21 | |
Precision Avi | |
Fc Tag and Avi Tag | |
Less than 1.0 EU / μg by the LAL method. | |
Powder | |
>95% as determined by SDS-PAGE |