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ACROBiosystems Biotinylated Human CTLA-4 Protein, His, Avitag™
Biotinylated Protein
457.25€ - 2011.89€
Specifications
Accession Number | NP_005205.2 |
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Molecular Weight (g/mol) | 17.2 kDa |
Source | Biotinylated Human CTLA-4, His,Avitag (CT4-H82E1) is expressed from human 293 cells (HEK293). It contains AA Ala 37 - Phe 162 (Accession # Q6GR94-1). |
Immunogen | Ala 37 - Phe 162 |
Storage Requirements | -20°C |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
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Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
15816527
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ACROBiosystems
CT4-H82E1-25UG |
25 μg |
457.25€
25µg |
Estimated Shipment: 02-05-2024
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15806527
|
ACROBiosystems
CT4-H82E1-200UG |
200 μg |
2011.89€
200µg |
Estimated Shipment: 02-05-2024
Log in to see stock. |
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Description
CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis.
This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag. The protein has a calculated MW of 17.2 kDa. The protein migrates as 22-30 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Specifications
NP_005205.2 | |
Biotinylated Human CTLA-4, His,Avitag (CT4-H82E1) is expressed from human 293 cells (HEK293). It contains AA Ala 37 - Phe 162 (Accession # Q6GR94-1). | |
-20°C | |
CTLA-4 | |
Human | |
PBS, pH7.4 | |
HEK293 | |
MABSol™ Biotin Labeled Proteins |
17.2 kDa | |
Ala 37 - Phe 162 | |
CTLA4,CD152 | |
Precision Avi | |
His Tag and Avi Tag | |
Less than 1.0 EU / μg by the LAL method. | |
Powder | |
>95% as determined by SDS-PAGE |