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ACROBiosystems Biotinylated HIV-1 [HIV-1/Clade B/C (CN54)] GP120 Protein, His, Avitag™

Biotinylated Protein

Brand:  ACROBiosystems GP0-V182E6-25UG

Additional Details : Weight : 0.00001kg

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Product Code. 15826867

  • 353.08€ / 25µg


Estimated Shipment: 11-10-2021
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Description

Description

Human Immunodeficiency Virus (HIV) can be divided into two major types, HIV type 1 (HIV-1) and HIV type 2 (HIV-2). HIV-1 is related to viruses found in chimpanzees and gorillas living in western Africa. HIV-2 is related to viruses found in sooty mangabeys. HIV-1 viruses may be further divided into groups. The HIV-1 group M viruses predominate and are responsible for the AIDS pandemic. Some of the HIV-1 group M subtypes are known to be more virulent or are resistant to different medications. HIV-2 viruses are thought to be less virulent and transmissible than HIV-1 M group viruses. Envelope glycoprotein GP120 (or gp120) is the name of the glycoprotein which forms the spikes sticking out of a HIV virus particle. gp120 is essential for virus entry into cells as it plays a vital role in seeking out specific cell surface receptors for entry. Three gp120s, bound as heterodimers to a transmembrane glycoprotein, gp41, are thought to combine in a trimer to form the envelope spike, which is involved in virus-cell attachment. One half of the molecular weight of gp120 is due to the carbohydrate side chains (the "e;glyco-"e; in "e;glycoprotein"e;). These are sugar residues which form something almost like a sugar "e;dome"e; over the gp120 spikes. This dome prevents gp120 from being recognised by the human immune response. As the HIV virus and the human CD4 cell come together, the gp120 binding site "e;snaps open"e; at the last minute.The glycoprotein gp120 is anchored to the viral membrane, or envelope, via non-covalent bonds with the transmembrane glycoprotein, gp41. It is involved in entry into cells by binding to CD4 receptors, particularly helper T-cells. Binding to CD4 is mainly electrostatic although there are van der Waals interactions and hydrogen bonds.
This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag. The protein has a calculated MW of 56.7 kDa. The protein migrates as 90-116 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Specifications

Specifications

Less than 1.0 EU / µg by the LAL method.
MABSol™ Biotin Labeled Proteins
Powder
>95% as determined by SDS-PAGE
Biotinylated HIV-1 [HIV-1/Clade B/C (CN54)] GP120, His,Avitag derived from the env. gene of HIV-1 strain CN54 gp160 (Accession # G4XFJ5-1 (E46G, T396A, A497T), Thr 36 - Arg 507) and glycosylated with N-linked sugars and expressed in HEK293 cells (at ACRObiosystems.)
-20°C
GP120
His Tag and Avi Tag
HEK293
HIV-1 (CN54)
56.7 kDa
25 µg
Thr 36 - Arg 507
GP120,GP120-CN54
Precision Avi
PBS, pH7.4
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