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Syk w/control Mouse anti-Human, Unlabeled, Clone: 4D10, BD

Mouse Monoclonal Antibody with Control

452.00€

Specifications

Antigen Syk w/control
Clone 4D10
Applications Western Blot
Classification Monoclonal
Conjugate Unconjugated
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Products 1
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15826708
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BD Biosciences
551816
50 μg This item has been discontinued and is no longer available. View the product for possible alternatives or contact our Technical Support team on +351 21 425 33 50 for assistance
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Description

Description

Syk is a member of the family of non-receptor type protein-tyrosine kinases and plays a crucial role in lymphocyte signaling and development. Syk is expressed in all haematopoietic cells and contributes to the signal transduction process by binding to a tyrosine-based activation motif (ITAM) of immune receptors, including Igα, TCRζ, CD3ε, FcεRIβ, and FceRIγ. Upon receptor activation, Syk binds to phosphorylated ITAMs via its two N-terminal SH2 domains thereby activating Syk and causing tyrosines in Syk to undergo auto-phosphorylation or phosphorylation. These phosphorylated sites can act as binding sites for other signaling molecules or help to regulate enzymatic activity. For example, in mast cells, Syk can activate downstream targets such as phospholipase Cγ1 and VAV. Studies in Syk-/- mast cells identified defects in both the ERK-MAP and JNK-MAP kinase pathways. Syk migrates as 72kDa in SDS/PAGE. (Predicted MW from SWISS-PROT is 72kDa; Accession number P43405).

Host Species: Mouse
Clone: 4D10
Isotype: IgG2a κ
Species Reactivity: Human
Immunogen: Human Syk peptide aa. 314-339

Western Blotting

Specifications

Specifications

Syk w/control
Western Blot
Unconjugated
RUO
Human
Human Syk peptide aa. 314-339
Primary
Store undiluted at -20°C.
4D10
Monoclonal
Mouse
Cell Biology
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
IgG2a
Affinity Purified
Videos
SDS
Documents

Documents

Product Certifications

For Research Use Only.