missing translation for 'onlineSavingsMsg'
Learn More

Serine Racemase Mouse, Unlabeled, Clone: 29, BD

Mouse Monoclonal Antibody

Brand:  BD Biosciences 612052

Additional Details : Weight : 0.01000kg

 View more versions of this product

Product Code. 15816089

This item has been discontinued and is no longer available. View the product for possible alternatives or contact our Technical Support team on +351 21 425 33 50 for assistance
View alternative products »


Description

Description

The majority of synapses in the central nervous system utilize glutamate as a neurotransmitter to produce rapid neuronal excitation. Glutamate has a diverse array of receptors that can be categorized into two groups: ionotropic and metabotropic. The ionotropic receptors are subdivided into two distinct types: 1) receptors for N-methyl D-aspartate (NMDAR) and 2) non-NMDA receptors for AMPA and kainate. NMDA receptors require coactivation at both glutamate and glycine sites. D-serine is a D-amino acid found in mammalian tissues that can act as a potent ligand for the glycine site on NMDA receptors. D-serine is made by the enzyme serine racemase, which is a member of the pyridoxal-5′ phosphate (PLP)-dependent enzyme family. Serine racemase mRNA is expressed in brain and liver, and serine racemase protein is expressed in glial cells. Degradation of D-serine by D-amino acid oxidase attenuates NMDA receptor-mediated calcium influx, and implicates D-serine as an endogenouse modulator of NMDA receptor function. Thus, glial cell production of D-serine via serine racemase activity may be an important system for modulation of synaptic transmission.

Host Species: Mouse
Clone: 29
Isotype: IgG1
Species Reactivity [for Features Main]: Mouse
Immunogen: Mouse serine racemase aa. 127-248

Immunofluorescence, Western Blotting

Specifications

Specifications

Serine Racemase
Monoclonal
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Mouse serine racemase aa. 127-248
50 μg
Cell Biology
Mouse, Rat
IgG1
Western Blot
29
Unconjugated
Mouse
Affinity Purified
RUO
Primary
Store undiluted at -20°C.
Product Suggestions

Product Suggestions

Videos
SDS
Documents

Documents

Certificates
Special Offers

Special Offers

For Research Use Only.