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Serine Racemase Mouse, Unlabeled, Clone: 29, BD
Mouse Monoclonal Antibody
338.00€ - 630.00€
Specifications
Antigen | Serine Racemase |
---|---|
Clone | 29 |
Concentration | 250μg/mL |
Applications | Western Blot |
Classification | Monoclonal |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
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Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
15826089
|
BD Biosciences
612053 |
150 μg |
630.00€
1 set |
Estimated Shipment: 22-05-2024
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15816089
|
BD Biosciences
612052 |
50 μg |
This item has been discontinued and is no longer available. View the product for possible alternatives or contact our Technical Support team on +351 21 425 33 50 for assistance |
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Description
The majority of synapses in the central nervous system utilize glutamate as a neurotransmitter to produce rapid neuronal excitation. Glutamate has a diverse array of receptors that can be categorized into two groups: ionotropic and metabotropic. The ionotropic receptors are subdivided into two distinct types: 1) receptors for N-methyl D-aspartate (NMDAR) and 2) non-NMDA receptors for AMPA and kainate. NMDA receptors require coactivation at both glutamate and glycine sites. D-serine is a D-amino acid found in mammalian tissues that can act as a potent ligand for the glycine site on NMDA receptors. D-serine is made by the enzyme serine racemase, which is a member of the pyridoxal-5′ phosphate (PLP)-dependent enzyme family. Serine racemase mRNA is expressed in brain and liver, and serine racemase protein is expressed in glial cells. Degradation of D-serine by D-amino acid oxidase attenuates NMDA receptor-mediated calcium influx, and implicates D-serine as an endogenouse modulator of NMDA receptor function. Thus, glial cell production of D-serine via serine racemase activity may be an important system for modulation of synaptic transmission.
Host Species: Mouse
Clone: 29
Isotype: IgG1
Species Reactivity [for Features Main]: Mouse
Immunogen: Mouse serine racemase aa. 127-248
Immunofluorescence, Western Blotting
Specifications
Serine Racemase | |
250μg/mL | |
Monoclonal | |
Mouse | |
Cell Biology | |
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
IgG1 | |
Affinity Purified |
29 | |
Western Blot | |
Unconjugated | |
RUO | |
Mouse, Rat | |
Mouse serine racemase aa. 127-248 | |
Primary | |
Store undiluted at -20°C. |
For Research Use Only.