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N-Cadherin Mouse, Unlabeled, Clone: 32, BD
Mouse Monoclonal Antibody
361.00€ - 565.00€
Specifications
| Antigen | N-Cadherin |
|---|---|
| Clone | 32 |
| Concentration | 250μg/mL |
| Applications | Western Blot |
| Classification | Monoclonal |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
15815709
|
BD Biosciences
610920 |
50 μg |
361.00€
1 set |
Estimated Shipment: 14-05-2024
Log in to see stock. |
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|
15825709
|
BD Biosciences
610921 |
150 μg |
565.00€
1 set |
Estimated Shipment: 15-05-2024
Log in to see stock. |
|||||
Description
Cadherins are a family of Ca2+;-dependent intercellular adhesion molecules that play a central role in controlling morphogenetic movements during development. Their function is regulated by association with the actin cytoskeleton by a complex of cytoplasmic proteins called the catenins (α, β, γ). Members of the cadherin family include P-cadherin, E-cadherin (uvomorulin), N-cadherin (neural cadherin), R-cadherin, cadherin 5, L-CAM, and EP-cadherin. N-cadherin mRNA is found at elevated levels in brain and heart and at a much lower level in liver. Mechanisms such as mRNA expression, cytokine modulation, and protease-mediated turnover modulate N-cadherin protein levels during development. In addition, N-cadherin function is indirectly regulated by endogenous kinases and phosphatases. Tyrosine phosphorylation of β-catenin complexed with N-cadherin results in dissociation of N-cadherin from actin. However, N-cadherin also interacts with a PTP1B-like phosphatase that dephosphorylates β-catenin and promotes N-cadherin/actin association. Thus, N-cadherin is an integral adhesion molecule whose function is regulated by protein-protein interactions and phosphorylation/dephosphorylation events.
Immunofluorescence, Western Blotting
Specifications
| N-Cadherin | |
| 250μg/mL | |
| Monoclonal | |
| Mouse | |
| Cell Biology | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| IgG1 | |
| Affinity Purified |
| 32 | |
| Western Blot | |
| Unconjugated | |
| RUO | |
| Chicken, Human, Mouse, Rat | |
| Mouse N-Cadherin aa. 802-819 | |
| Primary | |
| Store undiluted at -20°C. |
For Research Use Only.