missing translation for 'onlineSavingsMsg'
Learn More

Karyopherin α Mouse, Unlabeled, Clone: 2, BD

Mouse Monoclonal Antibody

Brand:  BD Biosciences 610485

Additional Details : Weight : 0.01000kg

 View more versions of this product

Product Code. 15815489

  • 261.00€ / 1 set


Estimated Shipment: 08-10-2021
Add to basket

Description

Description

The two step process of importing proteins into the nucleus involves the binding and interaction of several cytosolic and nuclear pore proteins. Proteins to be translocated into the nucleus contain a nuclear localization sequence (NLS) which is recognized and bound by carrier proteins in the cytosol. Heterodimers belonging to a highly conserved family of proteins called karyopherins are required for successful nuclear localization of cytosolic proteins. The α-subunits appear to function in the binding of NLS (both simple and bitartite NLS motifs), but both α- and β-subunits are required for successful docking to the nuclear envelope. ATP is required for complete translocation of proteins into the nucleus. Karyopherin α2 was first identified as Rch-1, an NLS receptor which interacts with the RAG-1 recombination-activating protein in developing B and T cells. Rch-1 has been reported to be 44% identical to karyopherin α1 (hSRP-1 /NPI-1).

Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

Specifications

Specifications

Karyopherin α
2
Unconjugated
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Mouse
IgG1
RUO
Store undiluted at -20°C.
Monoclonal
Western Blot
250μg/mL
Rch-1
Affinity Purified
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
50μg
Cell Biology
Primary
Canine, Drosophila, Human, Murine, Rat
Videos
SDS
Documents
Certificates

For Research Use Only.