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iNOS Mouse anti-Mouse, Unlabeled, Clone: 54, BD

Mouse Monoclonal Antibody

Brand:  BD Biosciences 610432

Additional Details : Weight : 0.01000kg

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Product Code. 15825459

  • 421.00€ / 1 set


Estimated Shipment: 13-10-2021
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Description

Description

Nitric oxide synthase (NOS), a cell-type specific enzyme, catalyzes the synthesis of nitric oxide (NO). NO is a short-lived radical that transmits cellular signals involved in vasorelaxation, neurotransmission, and cytotoxicity. In macrophages and other cell types, NOS (iNOS or macNOS) activity increases following exposure to cytokines (IFN-γ, TNF-α, and IL-1) and microbial products (lipopolysaccharide (LPS)). iNOS is activated independently of Ca2+/calmodulin and its level of expression is tightly controlled by several transcription factors, including NFκB. Data indicates that TGF-β affects translation of iNOS mRNA and decreases iNOS protein stability. Normally undetectable in brain tissue, iNOS mRNA has been observed in CNS tissues of animals under experimental pathologic conditions. iNOS and nNOS share 51% amino acid homology with the greatest degree of divergence in the calmodulin binding domain. This antibody has been reported to cross-react with nNOS and eNOS.

Immunofluorescence, Immunoprecipitation, Western Blotting

Specifications

Specifications

iNOS
54
Unconjugated
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Mouse
IgG2a, κ
RUO
Store undiluted at -20°C.
Monoclonal
Western Blot
250μg/mL
NOS Type II
Affinity Purified
IgG2a, κ
150μg
Cell Biology
Primary
Murine
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For Research Use Only.