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ILK Mouse, Unlabeled, Clone: 3, BD

Mouse Monoclonal Antibody

257.94€ - 625.00€

Specifications

Antigen ILK
Clone 3
Concentration 250μg/mL
Applications Western Blot
Classification Monoclonal
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15836029
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BD Biosciences
611803
150 μg
625.00€
1 set
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Estimated Shipment: 22-04-2024
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15826029
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BD Biosciences
611802
50 μg This item has been discontinued and is no longer available. View the product for possible alternatives or contact our Technical Support team on +351 21 425 33 50 for assistance
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Description

Description

Integrins are transmembrane receptors that mediate cell-cell or cell-matrix adhesion. All integrins are heterodimers composed of α and β subunits, which interact with extracellular matrix and cytoskeletal proteins. Signal transduction through intergin receptors may be regulated by integrin-linked kinase (ILK). ILK is a widely expressed Ser/Thr protein kinase that contains four ankyrin-like repeats in the N-terminal region, a phoshoinositide lipid-binding motif at amino acids 180-212, and an integrin binding site at amino acids 293-451. The ankyrin repeats interact with a LIM domain-only protein called PINCH that also binds the adaptor protein, Nck-2. This interaction implicates ILK in growth factor receptor pathways. In addition, the interaction of ILK with the cytoplasmic domains of integrin β1 and β3 subunits and localization of ILK to focal adhesion plaques suggests a role for ILK in the regulation of cell adhesion. Interestingly, overexpression of ILK in epithelial cells inhibits cell adhesion and stimulates cell cycle progression and tumorigenicity. Thus, ILK regulates signal transduction in many different cell signaling pathways.

Host Species: Mouse
Clone: 3
Isotype: IgG2
Species Reactivity [for Features Main]: Human
Immunogen: Human ILK aa. 326-452

Immunofluorescence, Western Blotting

Specifications

Specifications

ILK
250μg/mL
Monoclonal
Mouse
Cell Biology
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
IgG1
Affinity Purified
3
Western Blot
Unconjugated
RUO
Canine, Chicken, Human, Mouse, Rat
Human ILK aa. 326-452
Primary
Store undiluted at -20°C.
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For Research Use Only.