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CD38 Mouse anti-Human, BB515, Clone: HIT2, BD

Mouse Monoclonal Antibody

Brand:  BD Biosciences 564499

Additional Details : Weight : 0.01000kg

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Product Code. 15823689

  • 161.00€ / Each


Estimated Shipment: 13-10-2021
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Description

Description

The HIT2 monoclonal antibody specifically binds to CD38. The CD38 antigen is also known as T10, ADP-ribosyl cyclase 1, and cyclic ADP ribose hydrolase 1. CD38 is a 45 kDa type II single-chain transmembrane glycoprotein present on thymocytes, activated T cells and terminally differentiated B cells (plasma cells). CD38 is expressed by other cells including monocytes, macrophages, dendritic cells, NK cells, myeloid and erythroid precursors and some epithelial cells. The CD38 antigen acts as an ectoenzyme that catalyzes the synthesis and hydrolysis of a Ca++ mobilizing agent, cyclic ADP-ribose. This intracellular calcium plays an important role in cell signaling pathways leading to cellular growth, apoptosis, and differentiation. CD38 binds to CD31 and thus plays a role in lymphocyte adhesion to endothelial cells.

The antibody was conjugated to BD Horizon™ BB515 which was developed exclusively by BD Biosciences. With an excitation max of 490nm and an emission max of 515nm, BD Horizon BB515 can be excited by the 488nm laser and detected in a standard FITC set (e.g. 530/30-nm filter). This dye provides a much brighter alternative to FITC with less spillover into the PE detector.

Specifications

Specifications

CD38
HIT2
T10; ADP-ribosyl cyclase 1; Cyclic ADP-ribose hydrolase 1
Affinity Purified
IgG1, κ
RUO
Primary
Human
Flow Cytometry
BB515
Aqueous buffered solution containing ≤0.09% sodium azide.
Mouse
25 Tests
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
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For Research Use Only.