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CD247 with control Mouse anti-Human, Unlabeled, Clone: 8D3, BD

Mouse Monoclonal Antibody

Brand:  BD Biosciences 551034

Additional Details : Weight : 0.04000kg

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Product Code. 15816488

  • 399.00€ / Each


Estimated Shipment: 08-10-2021
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Description

Description

The T-cell receptor (TCR), expressed by thymus-derived lymphocytes, is a multi-component complex responsible for recognizing antigen in the context of MHC molecules. Ti is the antigen-specific binding component of the TCR. On the majority of peripheral T lymphocytes Ti is present as a disulfide-linked α - β heterodimer. A minor fraction express Ti as a γ- δ heterodimer. The Ti subunits are Ig-like, each containing V and C regions. Ti is noncovalently associated with an invariant set of molecules referred to as the CD3 subunits. CD3 appears early in thymocyte differentiation and remains expressed on all mature T lymphocytes. In the mouse, it consists of five chains, γ(gamma), δ (delta), ε (epsilon), ζ (zeta), and p21. The relative masses of the mouse CD3 chains are 21, 28, 26, 32 (dimer), and 21 kDa respectively.

The 8D3 antibody recognizes the ζ chain of the human and mouse T cell antigen receptor-associated CD3 complex. It reacts with 16 kDa unphosphorylated monomers and 32 kDa unphosphorylated dimers. It does not appear to recognize 21 kDa phosphorylated monomers or 42 kDa phosphorylated dimers. A synthetic peptide corresponding to a region of human CD3 ζ was used as immunogen.

Specifications

Specifications

CD247 with control
8D3
CD3ζ chain
Mouse
150μg
Store undiluted at -20°C.
Monoclonal
Human, Murine
Western Blot
Unconjugated
Affinity Purified
IgG1
RUO
Primary
Purified Mouse Anti-Human CD247 (150μg) 3 vials of 50μg each, Jurkat Cell Lysate (50μg)
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