ACE/Angiotensin Converting Enzyme FITC Monoclonal Antibody, Clone: i1A8, Invitrogen™

Description

This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Two most abundant alternatively spliced variants of this gene encode two isozymes - the somatic form and the testicular form that are equally active. Multiple additional alternatively spliced variants have been identified but their full length nature has not been determined.
Host Species: Mouse
Cross Reactivity: Human, Non-human primate
Isotype: IgG1
Clone: i1A8
Immunogen: Human lung CD143 (Angiotensin converting enzyme)
Formulation: 100 ug purified antibody (0.1mg/mL) in PBS with 1% BSA and 0.09% sodium azide
Synonyms: ACE1, CD143, DCP, DCP1, MGC26566, MVCD3
Uniprot Accession: P12821
Entrez GeneID: 1636
Gene Symbol: ACE
For FACS analysis, use 10ul of the suggested working dilution to label 1x10^6 cells in 100ul.