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CD138 Mouse anti-Human, PE, Clone: MI15, BD

Mouse Monoclonal Antibody

Brand:  BD Biosciences 552026

Additional Details : Weight : 0.02000kg

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Product Code. 15816758

  • 348.00€ / Each


Estimated Shipment: 06-10-2021
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Description

Description

The MI15 monoclonal antibody specifically binds to CD138 (Syndecan-1), an 85-92 kDa single chain transmembrane protein, strongly expressed on multiple-myeloma-derived cell lines and malignant plasma cell populations. It is also expressed on pre-B cells, immature B cells, and plasma cells, but not on mature circulating B-lymphocytes. Syndecan-1 is a member of the family of transmembrane heparan sulfate proteoglycans. It is also expressed on some non-hematopoietic cells, including embryonic mesenchymal cells, vascular smooth muscle cells, endothelial and neural cells. CD138 binds to many extracellular matrix proteins through its heparan sulfate side-chains, like fibronectin, collagen types I, III, and V, tenascin, thrombospondin, and antithrombin III. It is considered an extracellular matrix receptor that may serve as a co-receptor for fibroblast growth factor and related molecules. Monoclonal antibody MI15 blocks the binding of clone B-B4 but not clone DL-101 (other anti-syndecan-1 antibodies) by flow cytometric analysis.

This antibody is routinely tested by flow cytometric analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.

Specifications

Specifications

CD138
MI15
Syndecan; SDC; Syndecan 1; SDC1; SYND1
Affinity Purified
Human U266 and XG-1 Myeloma Cell Lines
100 Tests
Immunology
Primary
Human
Flow Cytometry
PE
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Mouse
IgG1, κ
RUO
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
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For Research Use Only.