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CD11b Rat anti-Mouse, V450, Clone: M1/70, BD
Rat Monoclonal Antibody
Brand: BD Biosciences 560456
Additional Details : Weight : 0.00790kg
Description
The M1/70 antibody reacts with the 170kDa α(M) chain of Mac-1 (CD11b/CD18, α(M)β(2) integrin), also known as complement receptor 3 (CR3), which mediates adhesion to C3bi and ICAM-1 (CD54). Mac-1 is expressed at varying levels on granulocytes, macrophages, myeloid-derived dendritic cells, natural killer cells, microglia, and B-1 cells. Mac-1 expression is rapidly up-regulated on neutrophils after activation, in the same time period that CD62L (L-selectin) is shed from the cell surface. M1/70 antibody reportedly blocks cell adherence and C3bi binding, but it does not block cell-mediated lysis. Cross-reaction of mAb M1/70 with CD11b on human monocytes, polymorphonuclear leukocytes, and NK cells has been reported.
Host Species: Rat
Clone: M1/70
Isotype: IgG2b, κ
Species Reactivity: Mouse
Immunogen: Mouse splenic Cells
Flow Cytometry
Specifications
| CD11b | |
| Monoclonal | |
| 0.2mg/mL | |
| Itgam; Integrin alpha-M; Ly-40; Mac-1a; Mac-1 alpha; CR3A; CR-3 alpha chain | |
| Rat | |
| Affinity Purified | |
| RUO | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
| Flow Cytometry | |
| M1/70 | |
| Violet Fluor 450 (V450) | |
| Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide. | |
| Mouse splenic Cells | |
| 25 μg | |
| Immunology | |
| Human, Mouse | |
| IgG2b κ |
For Research Use Only.