missing translation for 'onlineSavingsMsg'
Learn More

CD11b Rat anti-Mouse, Biotin, Clone: M1/70, BD

Rat Monoclonal Antibody

Brand:  BD Biosciences 557395

Additional Details : Weight : 0.01000kg

 View more versions of this product

Product Code. 15818908

  • 293.00€ / Each


Estimated Shipment: 07-10-2021
Add to basket

Description

Description

The M1/70 monoclonal antibody specifically binds to CD11b, also known as Integrin alpha M (Itgam or αM). CD11b is a 170-kDa type 1 transmembrane glycoprotein and belongs to the Integrin alpha chain family. CD11b serves as the alpha chain of the heterodimeric Mac-1 integrin (CD11b/CD18, αMβ2), also known as complement receptor 3 (CR3). Mac-1 mediates adhesion to ICAM-1 (CD54), ICAM-2 (CD102), fibrinogen and binding to C3bi. Mac-1 is expressed at varying levels on granulocytes, macrophages, myeloid-derived dendritic cells, natural killer cells, microglia, and B-1 B lymphocytes. Mac-1 expression is rapidly up-regulated on neutrophils after activation, in the same time period that CD62L (L-selectin) is shed from the cell surface. The M1/70 antibody reportedly blocks cell adherence and C3bi binding but does not block cell-mediated lysis. Cross-reaction of the M1/70 antibody with CD11b expressed on human monocytes, polymorphonuclear leukocytes, and NK cells has been reported.

Specifications

Specifications

CD11b
M1/70
Biotin
Aqueous buffered solution containing ≤0.09% sodium azide.
Rat
IgG2b, κ
RUO
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
Flow Cytometry
0.5mg/mL
Itgam; Integrin alpha-M; Ly-40; Mac-1a; Mac-1 alpha; CR3A; CR-3 alpha chain
Affinity Purified
Mouse Splenic Cells
0.1mg
Immunology
Primary
Human, Murine
Videos
SDS
Documentos
Certificados

For Research Use Only.