CD117 Mouse anti-Human, Brilliant Violet 421, Clone: YB5.B8, BD
Mouse Monoclonal Antibody
Brand: BD Biosciences 562434
Additional Details : Weight : 0.00800kg
The YB5.B8 monoclonal antibody specifically binds to CD117. CD117, also known as c-Kit, is a 145 kDa cell-surface glycoprotein with tyrosine kinase activity. CD117 is present on hematopoietic progenitor cell subsets, thymocytes, mast cells, hepatocytes and histiocytes.CD117 serves as a cytokine receptor for steel factor (SLF), also known as stem cell factor (SCF) or mast cell growth factor (MGF). The interaction of c-Kit and SLF is crucial to hematopoiesis, mast cell differentiation, melanogenesis, and germ cell development. The ability of
the YB5.B8 antibody to block the binding of c-Kit ligand is still controversial. The antibody was conjugated to Brilliant Violet 421 and has been developed in collaboration with Sirigen. With an Ex Max of 407-nm and Em Max at 421-nm, Brilliant Violet 421 can be excited by the violet laser and detected in the standard Pacific Blue filter set (eg, 450/50-nm filter). Brilliant Violet 421 conjugates are very bright, often exhibiting a 10 fold improvement in brightness compared to Pacific Blue conjugates.
Host Species: Mouse
Isotype: IgG1, κ
Species Reactivity: Human
|KIT; c-Kit; SCFR; PBT; Mast/stem cell growth factor receptor|
|Acute myelocytic leukemia blasts|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
|Brilliant Violet 421|
|Aqueous buffered solution containing BSA and ≤0.09% sodium azide.|
For Research Use Only.