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Carboxypeptidase E Mouse, Unlabeled, Clone: 35, BD
Mouse Monoclonal Antibody
343.00€ - 655.00€
Specifications
| Antigen | Carboxypeptidase E |
|---|---|
| Clone | 35 |
| Concentration | 250μg/mL |
| Applications | Western Blot |
| Classification | Monoclonal |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
15825629
|
BD Biosciences
610758 |
50 μg |
343.00€
1 set |
Estimated Shipment: 15-05-2024
Log in to see stock. |
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|
15835629
|
BD Biosciences
610759 |
150 μg |
655.00€
1 set |
Estimated Shipment: 13-05-2024
Log in to see stock. |
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Description
Carboxypeptidase E (CPE), also known as carboxypeptidase H and enkephalin convertase, is found as both a membrane-bound and a soluble glycoprotein in neuroendocrine tissues and adrenal-gland chromaffin granules. The C-terminus forms an amphiphilic α-helix, suggesting that this region is responsible for the membrane-bound form. Evidence suggests the active form of CPE is located in the secretory vesicles. CPE appears to have several functions. It is an exopeptidase that cleaves neuropeptides with C-terminal basic amino acids, producing an active form of the peptide. It has also been proposed that membrane-bound CPE is a sorting receptor for regulated secretory pathway (RSP) proteins in the TGN pituitary Golgi and secretory granule membranes. RSP proteins primarily consist of hormones and neuropeptides. Mice that carry a mutation in the CPE gene Cpe[fat] display endocrine disorders such as obesity, infertility, and hyperproinsulinemia. Furthermore, the same endocrine disorders are observed in Cpe[fat] mice where the CPE gene has been effaced by antisense RNA.
Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting
Specifications
| Carboxypeptidase E | |
| 250μg/mL | |
| Monoclonal | |
| Mouse | |
| Cell Biology | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| IgG1 | |
| Affinity Purified |
| 35 | |
| Western Blot | |
| Unconjugated | |
| RUO | |
| Human, Mouse, Rat | |
| Human Carboxypeptidase E aa. 49-200 | |
| Primary | |
| Store undiluted at -20°C. |
For Research Use Only.